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Development and function of hypothalamic Lhx6-positive neurons

Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 15 Mar 2021Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAnteriorAssay for Transposase-Accessible Chromatin using sequencingAutoregulationBasal Transcription FactorBasal transcription factor genesCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell SignalingCellular MigrationCellular MotilityConnector NeuronDefectDevelopmentElementsGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic studyHomeo DomainHomeostasisHypothalamic structureHypothalamusIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingMaintenanceMediatingMolecularNerve CellsNerve UnitNeural CellNeurocyteNeuronsPathway interactionsPhysiological HomeostasisPlayPopulationPosterior Hypothalamic RegionPosterior HypothalamusProcessRegulatory ElementRoleSignal TransductionSignal Transduction SystemsSignalingSleepSleep DisordersSleep Wake CycleSpecific qualifier valueSpecifiedTestingTranscript Expression AnalysesTranscript Expression AnalysisTranscription Factor Proto-OncogeneTranscription factor genesWorkanalyze gene expressionassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological signal transductioncell motilitydevelopmentalexperimentexperimental researchexperimental studyexperimentsexpression subtypesgene expression analysisgene expression assaygenetic analysisgenetic approachgenetic strategyhomeodomainhypothalamicinhibitory neuroninsightmigrationmolecular sub-typesmolecular subsetsmolecular subtypesmutantneural circuitneural circuitryneurocircuitryneuron developmentneuronalneuronal developmentnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypressureselective expressionselectively expressedsleep controlsleep diseasessleep dysfunctionsleep illnesssleep problemsleep regulationsleep to wake transitionsleep to wakefulness transitionsleep wakefulness cyclesleep/wake regulationsleep/wake transitionssocial rolesynaptic circuitsynaptic circuitrytherapeutic targettranscription factortranscription regulatory networktranscriptional profilingzona incerta

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Project Summary
GABAergic neurons of the dorsolateral hypothalamus play an essential role in both the regulating the
sleep/wake cycle, but little is known about the molecular mechanisms that control their development. We have
recently found that the LIM homeodomain transcription factor Lhx6 is necessary for development of a population
of…

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Development and function of hypothalamic Lhx6-positive neurons — JOHNS HOPKINS UNIVERSITY | UNITED STATES | Mar 2021 | Dev Procure