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Developing Selective P-catalysts for Dehydrative Transformations

Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025AcylationAmidesBiologicalCarboxylic AcidsCatalysisChemicalsChemistryCommunitiesComplementComplement ProteinsComplexComputer AnalysisEarthElectronicsElectronsElementsEstersFellowshipFoundationsFutureGoalsInterceptKnowledgeMediatingModernizationModificationNegative Beta ParticleNegatronsNitrilesOpticsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhosphorousPhosphorusPlanet EarthProcessR-Series Research ProjectsR01 MechanismR01 ProgramReactionResearchResearch GrantsResearch Project GrantsResearch ProjectsResearch ProposalsStructureTechniquesTestingThermodynamicThermodynamicsamidationbiologiccareercatalystcomplementationcomputational analysescomputational analysiscomputer analysesdesigndesigningelectronicelectronic deviceopticalpharmaceuticalskills

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Description preview

PROJECT SUMMARY/ABSTRACT
This proposal will elucidate the various steric and electronic parameters of a P-catalyst necessary for

enantioinduction in tandem amidation/amide functionalizations through deoxygenative P(III)/P(V) catalysis; an

important transformation for the synthesis of biologically active compounds. This proposal will first examine…

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