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Developing novel CAR T cell designs using combinatorial antigen detection

Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Apr 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025Antigen TargetingAntigensB cell malignancyB lymphoid malignancyB lymphomaB-Cell LymphomasBioinformaticsBiometricsBiometryBiostatisticsCAR T cellsCAR modified T cellsCAR-TCAR-TsCaliforniaCancersCell BodyCell Communication and SignalingCell SignalingCell Surface AntigensCell TherapyCell-Mediated Lympholytic CellsCellsClinicalClinical Trials DesignComprehensive Cancer CenterCross ReactionsCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesData CollectionDedicationsDepartment chairDetectionDiseaseDisorderDoctor of PhilosophyEcologic SystemsEcological SystemsEcosystemEngineeringEnvironmentFacultyFibroblastsFoundationsGene Down-RegulationGenerationsGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGoalsImmune mediated therapyImmune systemImmunocompetentImmunological Surface MarkersImmunologically Directed TherapyImmunotherapyIntracellular Communication and SignalingInvestigatorsKnowledgeLaboratoriesLeadLogicMacrophageMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMeasuresMedical OncologistMedical OncologyMentorsMentorshipMiceMice MammalsMolecularMurineMusNerve CellsNerve UnitNeural CellNeuroblastomaNeurocyteNeuronsNormal CellNormal TissueNormal tissue morphologyOrganPancreas AdenocarcinomaPancreas CancerPancreas Ductal AdenocarcinomaPancreatic AdenocarcinomaPancreatic CancerPancreatic Ductal AdenocarcinomaPatientsPb elementPh.D.PhDPharmacologyPhysiciansPositionPositioning AttributePostdocPostdoctoral FellowProductionProteinsReceptor ProteinRecombinant DNA TechnologyResearchResearch AssociateResearch PersonnelResearchersSafetySan FranciscoScientistSignal TransductionSignal Transduction SystemsSignalingSolidSolid NeoplasmSolid TumorSoluble Mpf/Mesothelin-Related ProteinSurface AntigensSynthetic immunologySystemT cells for CARTestingTherapeuticToxic effectToxicitiesTrainingTranscription RepressionTranslational Research EnterpriseTranslationsTreatment EfficacyTumor AntigensTumor CellTumor TissueTumor-Associated AntigenTwin Multiple BirthTwinsUniversitiesWorkanti-cancer immunotherapyanticancer immunotherapyantigen based detectionantigen detectionbiological signal transductioncancer antigenscancer immunologycancer immunotherapycancer microenvironmentcareer developmentcell based interventioncell engineeringcell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular engineeringcellular therapeuticcellular therapychimeric antigen T cell receptorchimeric antigen receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellsclinical practicecombinatorialcross reactivitycytokinedesigndesigningdetect antigenearly clinical trialearly phase clinical trialearly phase trialeffective therapyeffective treatmentengineered T cellsexperiencegene repressiongenetically engineeredgenetically engineered T-cellsheavy metal Pbheavy metal leadimmune competentimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunotherapy for cancerimmunotherapy of cancerimprovedintervention efficacykiller T cellleukemia/lymphomalymphoma/leukemiamalignancymesothelinmouse modelmurine modelneoplasm immunologyneoplasm/cancerneoplastic cellneuron toxicityneuronalneuronal toxicityneurotoxicitynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypancreatic cancer modelpancreatic malignancypancreatic tumor modelpost-docpost-doctoralpost-doctoral traineepreventpreventingprofessorprogramsreceptorreceptor expressionresearch associatessuccesssynthetic biologytherapeutic efficacytherapy efficacytooltransgenic T- cellstranslationtranslation research enterprisetranslational immunologytranslational research programtumortumor immunologytumor microenvironmenttumor-specific antigen

Applications closed.

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PROJECT SUMMARY/ABSTRACT
Candidate: The applicant, Greg Allen, MD/PhD, is a medical oncologist at UCSF with a long-term goal to lead

an independent laboratory-based translational research program focused on cellular therapies. The K08

application is key for his career development, providing him with (1) mentorship from a diverse team of scientists…

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Developing novel CAR T cell designs using combinatorial antigen detection — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | UN | Dev Procure