grant
Developing Lithium as a Disease-Modifying Therapy for Emphysema Using a Precision Medicine Approach
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 15 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAXILAXIN2AXIN2 geneAdultAdult HumanAffective DisordersAgreementAlveolusAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimal ModelAnimal Models and Related StudiesAssayAwardBeta Cadherin-Associated ProteinBeta-1 CateninBioassayBiologicalBiological AssayBlood ProteinsBody WaterBronchial AlveolusCOPDCUL-2Cause of DeathCell Communication and SignalingCell SignalingCell membraneChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseClinical TrialsCytoplasmic MembraneDataData SetDiffusionDiseaseDisorderDoseDrugsEatingElementsEmphysemaEnrollmentEnvironmentFood ChainFood IntakeGene variantGene x Environment InteractionGxE interactionHumanHydrogen OxideImmunoblottingIncrease lifespanIndividualIngestionIntracellular Communication and SignalingKnowledgeLassoLi+ elementLithiumLocationLungLung DiseasesLung ParenchymaLung Respiratory SystemLung TissueMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMedicationMental DepressionMiceMice MammalsModelingModern ManMood DisordersMurineMusNatural SourcePRO2286Paralysis AgitansParkinsonParkinson DiseaseParticipantPathogenesisPathway interactionsPatientsPharmaceutical PreparationsPlasma MembranePrimary ParkinsonismPrimary Senile Degenerative DementiaProtective AgentsProtective DrugsProteinsProteomicsPulmonary DiseasesPulmonary DisorderPulmonary EmphysemaRadialRadiographyRadiusResearchRoentgenographySFRP4SFRP4 geneSample SizeSecreted Frizzled-Related Protein 4SeveritiesSignal TransductionSignal Transduction SystemsSignalingSiteSliceSmokerSoilStructure of parenchyma of lungSupplementationTestingToxic effectToxicitiesUnited StatesValidationVariantVariationWaterWater SupplyWestern BlottingWestern ImmunoblottingWorkadulthoodairflow limitationairflow obstructionairway limitationairway obstructionallelic variantanimal databeta catbeta cateninbiologicbiological signal transductionboost longevitychronic obstructive pulmonary disordercohortdepressiondiffuseddiffusesdiffusingdiffusionsdisease of the lungdisease phenotypedisorder of the lungdrinking waterdrug/agentefficacy testingelongating the lifespanemphysematousenhance longevityenrollenvironment effect on geneexperienceextend life spanextend lifespanextend longevityfoster longevityfrpHEgene environment interactiongenetic variantgenomic biomarkergenomic datagenomic datasetgenomic markergenomic variantground watergroundwaterimprove lifespanimprove longevityinclusion criteriaingestlifespan extensionlung developmentlung disordermodel of animalnovelobstructed airflowobstructed airwaypathwayperipheral bloodphenomicsplasmalemmapotential biological markerpotential biomarkerprecision medicineprecision-based medicinepreventpreventingprimary degenerative dementiaprolong lifespanprolong longevitypromote lifespanpromote longevityprotein blottingradiological imagingrepairrepairedrespiratory airway obstructionresponsesenile dementia of the Alzheimer typesuicidal risksuicide risksupport longevityvalidationsβ-catenin
Description preview
PROJECT SUMMARY/ABSTRACT
Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death among adults in
the United States; nonetheless, we lack disease-modifying therapies. Herein, we hypothesize that lithium may
be a novel disease-modifying agent for emphysema in smokers.
Lithium is an abundant naturally occurring element…
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