grant
Developing Human Induced Pluripotent Stem Cell Precision Oncology Models
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 17 Sept 2018Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAreaBrachydanio rerioBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCNS Nervous SystemCancer ModelCancerModelCancersCausalityCell BodyCellsCentral Nervous SystemChemotactic CytokinesChildhood CancersCollaborationsCostello syndromeCutaneousDNA mutationDanio rerioDedicationsDiseaseDisorderEncephalonEngineeringEtiologyFaceFundingGenerationsGenetic ChangeGenetic defectGenetic mutationGerm-Line MutationGrantHereditary MutationHomologous Chemotactic CytokinesImmuneImmunesIn VitroInstitutionIntercrinesInternationalInvestigatorsLaboratoriesLeadershipMEKsMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant childhood cancerMedicalModelingMolecularMutationNerveNerve CellsNerve UnitNervous SystemNervous System NeoplasmsNeural CellNeuraxisNeurocyteNeurofibromatosis 1Neurofibromatosis INeurologic Body SystemNeurologic Organ SystemNeuronsNeurosciencesOutcome StudyPNS NeoplasmPNS TumorPathogenesisPatientsPeripheral Nerve NeoplasmsPeripheral Nerve TumorsPeripheral Nervous System NeoplasmsPeripheral Nervous System TumorPeripheral NeurofibromatosisPersonsPostdocPostdoctoral FellowPre-Clinical ModelPreclinical ModelsRecklinghausen Disease of NerveRecklinghausen's diseaseRecklinghausen's neurofibromatosisResearchResearch AssociateResearch PersonnelResearchersRisk AssessmentSIS cytokinesSpecialistSyndromeTherapeuticTranslational ResearchTranslational ScienceType 1 NeurofibromatosisType I NeurofibromatosisUniversitiesWashingtonWorkZebra DanioZebra FishZebrafishadulthoodcancer geneticscancer immunologycancer in a childcancer in childrencancer predispositioncancer progenitorcancer progenitor cellscancer stem cellcancer stem like cellcausationcell repositorycellular repositorychemoattractant cytokinechemokinechild with cancerchildhood malignancyclinically actionableconditional knock-outconditional knockoutdesigndesigningdisease causationengineered progenitor cellsengineered stem cellsexperiencefacesfacialfaciocutaneoskeletal (FCS) syndromefaciocutaneoskeletal syndromegenome mutationgerm-line defectgermline varianthiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimmune activatorin vivoindividualized cancer careindividualized oncologyindividualized therapeuticinduced human pluripotent stem cellsmalignancymalignant progenitormalignant stem cellmutantneoplasm immunologyneoplasm/cancernervous system tumorneuronalneuronal excitabilitynoveloncogenic progenitoroncogenic stem cellspediatric cancerpediatric malignancypersonalized oncologypersonalized therapeuticpost-docpost-doctoralpost-doctoral traineeprecision cancer careprecision cancer medicineprecision oncologyprofessorprogenitor like cancer cellprogramsresearch associatesstem like cancer celltooltranslation researchtranslational investigationtumortumor growthtumor immunologytumor xenografttumors in the brainvon Recklinghausen Disease
Description preview
Abstract
This proposal was specifically designed to support a dedicated Research Specialist with extensive experience
in human induced pluripotent stem cell (hiPSC) engineering to study the cellular and molecular mechanisms
underlying the formation and progression of central and peripheral nervous system tumors relevant to the
identification of…
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