grant
Developing an "aging" model using iPSC-derived RPE cells
Organization NATIONAL EYE INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025APOEAffectAge related macular degenerationAge-Related MaculopathyAgingApo-EApoE proteinApolipoprotein EAtrophicAtrophyAutoregulationBlindnessBlood SerumBody TissuesCell AgingCell DeathCell Membrane PermeabilityCell SenescenceCellular AgingCellular SenescenceChoroidComplementComplement ProteinsDefectDepositDepositionDevelopmentDiseaseDisorderDrugsDysfunctionElderlyEpitheliumExhibitsFamilial juvenile macular degeneration syndromeFibroblastsFunctional disorderGenetic RiskGoalsHomeostasisHumanIn VitroIndividualJuvenile onset macular degenerationMediatingMedicationMendelian diseaseMendelian disorderMendelian genetic disorderModelingModern ManOuter pigmented layer of retinaPathogenesisPathologyPathway interactionsPatientsPhagocytesPhagocytic CellPhagocytosisPharmaceutical PreparationsPhenotypePhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiological HomeostasisPhysiopathologyPigment cell layer of retinaPigmented layer of retinaProtocolProtocols documentationReplicative SenescenceReportingResistanceRetinaRetinal DiseasesRetinal DisorderRetinal Pigment EpitheliumRetinal pigment epithelial cellsRisk-associated variantSTGD3STGD3 diseaseSerumSignal PathwaySkinStargardt diseaseStargardt macular dystrophyStargardt syndromeStargardt's diseaseStargardt-3Stargardt-3 macular dystrophyStargardt-like macular dystrophyStressStructure of retinal pigment epitheliumSystemTherapeutic InterventionTissuesVisual Receptoradvanced ageage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophyaging associatedaging relatedamebocytecomplementationdevelopmentaldrug/agentfat metabolismfundus flavimaculatusgeographic atrophygeriatriciPSiPSCiPSCsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinherited retinal degenerationinsoluble aggregateintervention therapylipid metabolismlipidomicsmembrane permeabilitymonogenic diseasemonogenic disordermonolayernecrocytosispathophysiologypathwaypostmitoticprotein aggregateprotein aggregationreplicative agingresistantretina diseaseretina disorderretinopathyrisk allelerisk generisk genotyperisk locirisk locusrisk variantsenile macular diseasesenior citizensingle-gene diseasesingle-gene disordervision lossvisual loss
Description preview
Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in the developed world. Dysfunction of the retinal pigment epithelium (RPE) is thought to initiate early AMD, while RPE degeneration drives progression to geographic atrophy, an advanced stage of AMD characterized by photoreceptor cell death and irreversible…
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