grant
Developing a Multi-Organ Multi-Omics Computational Framework for StudyingMammalian Iron Systems Biology
Organization JACKSON LABORATORYLocation BAR HARBOR, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AddressAffectAnemiaAutoregulationBiologicalBiologyBloodBlood Reticuloendothelial SystemBody SystemBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCausalityCell BodyCell Communication and SignalingCell SignalingCellsCommunicationComplexCouplesDNADeoxyribonucleic AcidDiseaseDisorderEffectivenessErythropoiesisEtiologyFe absorptionFe chelationFe deficiencyFe elementFe metabolismFe overloadFe supplementationFutureGoalsHealthHistopathologyHomeostasisImpairmentIndividualIntestinalIntestinesIntracellular Communication and SignalingIronIron ChelationIron Metabolism DisordersIron OverloadIron chelatorIron deficiency anemiaKidneyKidney Urinary SystemLaboratoriesLinkMolecularOrganOrgan SystemPatientsPhenotypePhysiological HomeostasisResearchSignal TransductionSignal Transduction SystemsSignalingSpleenSpleen Reticuloendothelial SystemSymptomsSystems BiologyTechnologyThe Jackson LaboratoryTherapeuticTissuesWomanabsorptionbiologicbiological signal transductionbowelburden of diseaseburden of illnesscausationcomputational frameworkcomputer frameworkdesigndesigningdisease burdendisease causationerythroid developmentimprovedinnovateinnovationinnovativeiron absorptioniron deficiencyiron disorderiron metabolismiron supplementationmultiomicsmultiple omicsnovelpanomicspersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentprogramsrenaltranscriptomics
Description preview
PROJECT SUMMARY/ABSTRACT
Iron disorders are caused by changes in iron levels in blood, tissues, or both. Iron deficiency, which can lead to
anemia, represents a major component of the global disease burden worldwide, especially in women. Iron
deficiency-related anemia affects >1.2 billion individuals worldwide, and iron deficiency without anemia…
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