grant
Determining Uropathogenic Escherichia coli Fitness Factors in Different Gut Niches
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Mar 2026Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20261,2,3-Propanetriol1,2,3-TrihydroxypropaneAddressAerobicAffectAlimentary CanalAntibiotic AgentsAntibiotic DrugsAntibioticsAntimicrobial ResistanceArabinoseBacteriaBacterial InfectionsBar CodesBladderBladder Urinary SystemC57BL/6 MouseCandidate Disease GeneCandidate GeneClinicalCulture MediaD-GlucoseDNADataDefectDeoxyribonucleic AcidDependenceDextroseDietDigestive TractDisproportionate number of femalesDisproportionate number of womenDisproportionately affects femalesDisproportionately affects womenDisproportionately impacts femalesDisproportionately impacts womenDisproportionately in femalesDisproportionately in womenE coliE. coliEnabling FactorsEnergy-Generating ResourcesEnvironmentEscherichia coliFecesFiberGI TractGI colonizationGI microbiomeGI microbiotaGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGene ExpressionGeneralized GrowthGenesGerm-FreeGlucoseGlycerinGlycerolGnotobioticGnotobioticsGrowthHourIn VitroIndividualInfection preventionInterventionIntestinalIntestinesJobsKnowledgeL-ArabinoseLibrariesLiteratureLocationMetabolicMiceMice MammalsMiscellaneous AntibioticModelingMolecularMucinsMucosaMucosal Immune ResponsesMucosal TissueMucous MembraneMucous body substanceMucusMucus GlycoproteinMurineMusNutritionalOccupationsPathogenesisPersonsPredispositionPreparationPrevent infectionProfessional PositionsRecurrenceRecurrentReportingRoleSusceptibilityTestingTissue GrowthUPECUrinary tractUrinary tract infectionUrinary tract infectious diseaseUrineUropathogenic E coliUropathogenic E. coliUropathogenic Escherichia coliWomanWorkalimentary tractanti-microbial resistantantibiotic designarmbacteria infectionbacterial diseasebarcodebowelcandidate identificationcomparativedietsdigestive canaldigestive tract microbiomeenergy sourceenteric microbial communityenteric microbiomeenteric microbiotaexperimentexperimental researchexperimental studyexperimentsfecal samplefemale biasfemale predominancefemale preponderancefitnessgastrointestinal microbial floragastrointestinal microbiomegastrointestinal tract colonizationgenome wide screengrowth mediagut colonizationgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehost microbe associationhost microbe relationshiphost-microbe interactionshost-microbial interactionshost-microorganism interactionsin vivoinsightinterestintestinal biomeintestinal colonizationintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloramembermicrobialmucousmutantnutritiousontogenyphysiologic modelpredominance in femalespredominance in womenpreparationspreventpreventingresidenceresidential buildingresidential siteresistance to anti-microbialresistant to antimicrobialsocial rolestoolstool samplestool specimentoolurinary bladderurinary infectionwomen's predominancewomen's preponderance
Description preview
PROJECT SUMMARY
Urinary tract infections (UTIs) affect approximately 150 million people per year worldwide. An estimated
50% of women report having had a UTI at some point in their lifetime. Antibiotic use, while the mainstay of UTI
treatment, has contributed to the rise in antimicrobial resistance. Uropathogenic E. coli (UPEC) is implicated in…
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