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Determining the role of astrocyte BMP signaling in cortical astrocyte heterogeneity
Organization SALK INSTITUTE FOR BIOLOGICAL STUDIESLocation La Jolla, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2026 β οΈ
NIHUS FederalResearch GrantFY2025AQP4 proteinASDAbscissionAddressAmmon HornAssayAstrocytesAstrocytusAstrogliaAutismAutistic DisorderAutomobile DrivingBMP receptorBMPR-IIBMPR2BMPR2 geneBRK-3 proteinBioassayBiological AssayBone Morphogenetic Protein Receptor, Type II (Serine/Threonine Kinase) GeneBone-Derived Transforming Growth FactorBrainBrain Nervous SystemBrain regionCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCellsCerebellumComplexConnector NeuronCornu AmmonisCuesDPC4Deleted in Pancreatic CarcinomaDevelopmentDifferential Gene ExpressionDown-RegulationDrosophila Homolog of Mothers Against Decapentaplegic 4Early Infantile AutismElectrophysiologyElectrophysiology (science)EncephalonExcisionExpression SignatureExtirpationFamilyFutureGene ExpressionGene Expression ProfileGene TranscriptionGenesGeneticGenetic TranscriptionGliaGlial CellsGoalsGrowth AgentsGrowth FactorGrowth SubstancesHeterogeneityHippocampusImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn VitroInfantile AutismIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingKanner's SyndromeKolliker's reticulumLabelMADH4MADH4 geneMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatorMembraneMiceMice MammalsMilk Growth FactorMolecularMorphologyMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurogliaNeuroglial CellsNeurological Development DisorderNeuronsNeurophysiology / ElectrophysiologyNon-neuronal cellNonneuronal cellPathway interactionsPlatelet Transforming Growth FactorPlayProductionProtein SecretionProteinsProteins Growth FactorsProteomicsRNA ExpressionRNA SeqRNA sequencingRNAseqRemovalRoleSHHSHH geneSMA- and MAD-Related Protein 4SMAD4Signal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSonic HedgehogSourceSurgical RemovalSynapsesSynapticTGF BTGF-betaTGF-Ξ²TGFbetaTGFΞ²TestingThalamic structureThalamusTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneUpregulationWorkantagonismantagonistaquaporin 4astrocytic gliaautism spectral disorderautism spectrum disorderautistic spectrum disorderbiological signal transductionbone morphogenetic protein receptor IIbone morphogenetic protein receptor type IIbone morphogenetic protein receptorscell culturecell culturesdevelopmentaldifferentiation factorsdrivingelectrophysiologicalexcitatory neuronexperimentexperimental researchexperimental studyexperimentsgene expression patterngene expression signaturehippocampalin vivoinhibitorinhibitory neuroninnovateinnovationinnovativeinsightmembermembrane structuremorphogenic factorsmorphogensnerve cementnervous system developmentneurodevelopmental diseaseneuronalneuronal circuitneuronal circuitrypathwaypreventpreventingprogramsresectionsNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssynapsesynapse functionsynaptic functionthalamictranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtype II BMP receptor
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PROJECT SUMMARY
Astrocytes, like neurons, display regional and intra-regional heterogeneity in both function and transcriptional
state. This heterogeneity impacts neighboring neurons, making it imperative to identify on a molecular level what
drives regional specialization of astrocytes. This question is addressed in the cortex, where astrocytesβ¦
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