grant
Determining the relationship between NAAG and memory deficits in schizophrenia in mid- to late- life
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 12 Jun 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAffectAfter CareAfter-TreatmentAftercareAgeAgingAgonistAnimal ModelAnimal Models and Related StudiesAttentionAutoreceptorsAutoregulationBehavioralBrainBrain Nervous SystemBrain imagingCell Communication and SignalingCell SignalingChronic SchizophreniaClinical TrialsCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive Retention DisordersCognitive SymptomsCognitive declineCognitive deficitsCognitive function abnormalDataDevelopmentDisturbance in cognitionDysfunctionElderlyEncephalonFOLHFOLH1FOLH1 geneFolate Hydrolase 1Functional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGCP2GenesGenetic PolymorphismGlutamate Carboxypeptidase IIGlutamatesGoalsHomeostasisHumanImmediate MemoryImpaired cognitionIndividualIntracellular Communication and SignalingInvestmentsL-GlutamateLearningLightLinkMR ImagingMR SpectroscopyMR TomographyMRIMRIsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasurementMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMemory DeficitMemory DisordersMemory impairmentModern ManMonkeysN-Acetylated Alpha-Linked Acidic Dipeptidase 1N-acetyl-1-Asp-GluN-acetyl-aspartyl-glutamateN-acetylaspartylglutamateNAALAD1NAALADase INMR ImagingNMR TomographyNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNeuronal TransmissionNeurotransmittersNuclear Magnetic Resonance ImagingPSMPSMAParietalPatientsPatternPeptidesPerformancePhotoradiationPhysiological HomeostasisPhysiopathologyPreclinical dataProstate-Specific Membrane AntigenRDoCResearch Domain CriteriaRisk-associated variantRoleSchizophreniaSchizophrenic DisordersShort-Term MemorySignal TransductionSignal Transduction SystemsSignalingSymptomsSynapsesSynapticTestingTimeVariantVariationVisualZeugmatographyadulthoodadvanced ageadvanced age ratsaged rataged ratsagesassess effectivenessaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbiomarker developmentbrain circuitrybrain visualizationclinical relevanceclinically relevantcognitive defectscognitive dysfunctioncognitive losscompare to controlcomparison controldementia praecoxdetermine effectivenessdevelop therapydevelopmentaleffective therapyeffective treatmenteffectiveness assessmenteffectiveness evaluationelderly ratsevaluate effectivenessexamine effectivenessexperiencefMRIfunctional disabilitygenome scalegenome-widegenomewidegeriatricgeriatric ratsglia signalingglial signalingglutamatergichealthy aginghealthy human aginghuman dataimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedinhibitorinsightintervention developmentlate in lifelate lifemGluR3memory dysfunctionmetabotropic glutamate receptor 3model of animalnerve signalingneuralneural signalingneuroimaging biomarkerneuroimaging markerneuronal signalingneurotransmissionold ratspathophysiologypolymorphismpost treatmentpreclinical findingspreclinical informationpresynapticrisk allelerisk generisk genotyperisk locirisk locusrisk variantschizophrenia riskschizophrenicsenior citizensocial rolesynapsetherapy developmenttreatment developmenttreatment trialworking memory
Description preview
Project Summary
Cognitive deficits are a core feature of schizophrenia and are particularly prominent in patients of advanced
age. In fact, schizophrenia patients are likely to experience worsening cognitive symptoms in mid- to late-life.
There is an abundance of evidence suggesting that targeting glutamate-mediated neurotransmission could…
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