grant
Determinants of Post-Treatment Phenotypes in Lyme Disease
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AcuteAddressAfter CareAfter-TreatmentAftercareAntibiotic TherapyAntibiotic TreatmentAnxietyAutoantibodiesAutoantigensAutoimmune MechanismAutoimmune ProcessAutologous AntigensB burgdorferiB. burgdorferiBiologyBlood PressureBlood SerumBorrelia burgdorferiBorrelia burgdorferi sensu strictoBorreliella burgdorferiCausalityCellular Metabolic ProcessClinicalCo-cultureCocultivationCocultureCoculture TechniquesComplexDataDevelopmentDiagnostic FindingsDiseaseDisease PathwayDisorderDysfunctionELISAEnvironmentEnzyme-Linked Immunosorbent AssayEtiologyEventFDA approvedFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderFutureGoalsGrantHealthHistoryHumanImmuneImmune PrecipitationImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyImmunoprecipitationIn VitroIndividualInfectionInterventionKnowledgeLaboratoriesLongitudinal StudiesLyme BorreliosisLyme DiseaseLyme Disease SpirocheteMental DepressionMetabolicMetabolic PathwayMethodsModelingModern ManModernizationMolecularMusculoskeletal PainNeurologic ManifestationsNeurologic Signs and SymptomsNeurologic SymptomsNeurological ManifestationsNeurological Signs and SymptomsOutcomePBMCParticipantPathogenesisPathway interactionsPatientsPeripheral Blood Mononuclear CellPersonsPhenotypePhysiologic pulsePhysiopathologyPreventative interventionProcessProspective, cohort studyProtein ArrayProtein BiochipsProtein ChipsProtein MicroarrayProtein MicrochipsPsychosocial FactorPublishingPulseQOLQuality of lifeRNA SeqRNA sequencingRNAseqRecording of previous eventsReportingResearchRiskRisk AssessmentRisk FactorsSamplingSampling StudiesScientific Advances and AccomplishmentsSelf-AntigensSeriesSerologySerumSigns and SymptomsSortingStandardizationStressful EventSubgroupSymptom BurdenSymptomsSyndromeTestingTherapeuticTimeTranslational Research EnterpriseTranslationsTreatment outcomeUnited StatesUniversitiesVector-borne diseaseVector-borne infectious diseaseVector-transmitted diseaseVector-transmitted infectious diseaseWorkacute infectionautoimmune antibodyautoreactive antibodybacterial disease treatmentbacterial infectious disease treatmentbiobankbiorepositorycandidate identificationcausationcell metabolismcellular metabaolismclinical careclinical phenotypeclinical practiceclinical relevanceclinically relevantcohortcytokinedepressiondevelopmentaldisease causationenzyme linked immunoassayflow cytophotometryhigh dimensionalityhistoriesinnovateinnovationinnovativeinsightintervention for preventionlong-term studylongitudinal outcome studieslyme spirochetemachine learned algorithmmachine learning algorithmmachine learning based algorithmneural manifestationnovelpain symptompainful symptomparticipant enrollmentpathophysiologypathwaypatient enrollmentpatient populationpatient profilepatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespharmacologicpost treatmentpreventpreventingprevention interventionpreventional intervention strategypreventive interventionprofiles in patientspsychosocial variablesrecruitscientific accomplishmentsscientific advancesself reactive antibodysexstressful experiencestressful life eventstressful life experiencetherapeutic targettranscriptome sequencingtranscriptomic sequencingtranslationtranslation research enterprisetranslational research programvector-borne illnessvectorborne diseasevectorborne illnessvectorborne infectious disease
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PROJECT SUMMARY/ABSTRACT
It is unknown why some patients regain their pre-morbid health following appropriate treatment for Lyme disease
while others progress to develop post-treatment Lyme disease (PTLD). Significant prior published and
preliminary data suggest that variability in clinical, immunologic, and metabolic factors at the onset of…
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