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Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention

Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 22 Jan 2021Deadline 31 Oct 2025 ⚠️
NIHUS FederalResearch GrantFY20254-Nitroquinoline-1-oxide4-Nitroquinoline-N-oxideAflatoxin B1AlgorithmsAristolochic AcidsBenchmarkingBest Practice AnalysisBioinformaticsBloodBlood Reticuloendothelial SystemBlood SampleBlood leukocyteBlood specimenBody TissuesCDDPCancer CauseCancer EtiologyCancer PatientCancersCell BodyCell LineCellLineCellsCharacteristicsChemicalsChronicCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumClassificationComputational toolkitConsumptionCustomCysplatynaDNA SequenceDNA mutationDNA seqDNA sequencingDNAseqDataDetectionDevelopmentDichlorodiammineplatinumEnvironmentEnvironmental ExposureEnvironmental genotoxicantEpidemiologistEventExperimental ModelsExposure toFutureGenetic ChangeGenetic defectGenetic mutationGenomeGenotoxinsGoalsHumanHuman FigureHuman bodyIn VitroIndividualInterceptInterventionLeukocytesLeukocytes Reticuloendothelial SystemLife StyleLifestyleMalignant NeoplasmsMalignant TumorMarrow leukocyteMeasurementMeasuresMethodologyModern ManMonitorMutagensMutationMutation DetectionNormal CellNormal TissueNormal tissue morphologyOutcomePassive SmokingPatientsPatternPersonsPeyrone's ChloridePeyrone's SaltPlatinumPlatinum BlackPlatinum DiamminodichlorideProcessPt elementQuinoline, 4-nitro-, 1-oxideResearchRiskSamplingSomatic CellSomatic MutationSourceStrains Cell LinesSurvey InstrumentSurveysSystemSystematicsTestingTissuesValidationWater IntakeWater consumptionWater contaminationWhite Blood CellsWhite Cellbenchmarkcancer cell genomecancer genomecancer preventionchemotherapycis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumclinical practicecohortcombinatorialcomputational toolboxcomputational toolscomputational toolsetcomputerized toolscontaminated watercultured cell linecustomsdevelopmentalenvironmental mutagenesisenvironmental mutagensexperimentexperimental researchexperimental studyexperimentsgenome mutationgenotoxic agentimprintin vivoinnovateinnovationinnovativeinvoluntary smokingmalignancymouse modelmurine modelneoplasm/cancernew approachesnon-invasive monitornoninvasive monitornovelnovel approachesnovel strategiesnovel strategypreventpreventingsecond hand smokingsecondhand smokingsomatic varianttumor genomevalidationswhite blood cellwhite blood corpuscle

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PROJECT SUMMARY
Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational
processes due to environmental exposures, lifestyle choices, defective cellular machineries, and even normal
cellular activities. Each mutational process imprints a characteristic pattern of mutations on the genome of…

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