grant

Design of novel antitumor immunotherapies based on tumor-associated glycopeptide antigens

Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Animal ModelAnimal Models and Related StudiesAntibodiesAntibody-drug conjugatesAntigen PresentationAntigen-Presenting CellsAntigensAntimetastatic AgentBindingBiodistributionBiologicalBiological FunctionBiological ProcessBlood SerumBody TissuesCA AntigensCAR T cellsCAR modified T cellsCAR-TCAR-TsCBP-30CBP-35CBP35Cancer-Associated Carbohydrate AntigensCancersCarbohydrate-Binding Protein 35CarbohydratesCell AdhesionCell BodyCellsCellular AdhesionChemistryClinical Treatment MoabCrystallizationDevelopmentDiagnosticDisaccharidesEncapsulatedEngineeringEpsilon-Binding ProteinExhibitsFamilyFluorescent ProbesFosteringFutureGalectin 3GlucansGlucose PolymerGlycansGlycopeptidesGlycoproteinsGoalsHL-29HeterograftHeterologous TransplantationHumanIgE Binding ProteinIgEBPImmune responseImmunologyIn VitroL-29 LectinL-31L-34L-SerineL-ThreonineL30 LectinLGALS3LeadLectinLectin InhibitorLinkMac-2 AntigenMacrophage-2 AntigenMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMediatingMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModern ManMolecular InteractionMonoclonal AntibodiesMucinsMucus GlycoproteinMurineMusNIR dyeNatureNeoplasm MetastasisPDX modelPancreasPancreas CancerPancreaticPancreatic CancerPatient derived xenograftPb elementPeptidesPolyglucosesPolysaccharidesPositionPositioning AttributePreparationPropertyProstateProstate GlandProstatic GlandProteinsReportingResearchSecondary NeoplasmSecondary TumorSerineSerumSodium ChlorideSpinal ColumnSpineStaining methodStainsStructureT cells for CARTandem Repeat SequencesTandem RepeatsTestingTherapeuticThompson-Friedenreich AntigenThomsen-Friedenreich antigenThreonineTissuesToxic effectToxicitiesTumor CellTumor-Associated Carbohydrate AntigensVaccine DesignVaccinesVertebral columnWorkXenograftXenograft procedureXenotransplantationaccessory cellanti-tumor immune responseanti-tumor immune therapyanti-tumor immunotherapybackbonebiochemical toolsbiochemistry toolsbiologiccancer metastasiscarbohydrate binding proteincarbohydrate receptorchimeric antigen T cell receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellscommercializationdectin 1designdesigningdevelopmentalglycomimeticsgold nano particlegold nanoparticleheavy metal Pbheavy metal leadhost responseimmune system responseimmunogenimmunoresponsein vivoin vivo ModelinterestmAbsmalignancymodel of animalmonoclonal Absnano goldnano particlenano vaccinenano-sized particlenanoGoldnanomaterialsnanoparticlenanosized particlenanovaccinenear IR dyenear infrared dyeneoplasm immunotherapyneoplasm/cancerneoplastic cellnoveloverexpressoverexpressionpancreatic malignancyparticlepatient derived xenograft modelpreparationsprogramsprotein bound carbohydrateresponse to therapyresponse to treatmentsaltself assemblytargeted agenttherapeutic responsetherapy responsetooltreatment responsetreatment responsivenesstumortumor cell metastasistumor growthtumor immune therapytumor immunotherapyvaccine platformxeno-transplantxeno-transplantation
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Specific Aim 1. Optimization of both active (vaccine) and passive (antibodies) MUC4-TF-based agents for combined tumor immunotherapy: The commercialized antibody discussed in the last cycle was a first successful attempt at discovering a tumor-selective glycopeptide-based mAb. We have completed a biodistribution study that showed unequivocally…

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Design of novel antitumor immunotherapies based on tumor-associated glycopeptide antigens — DIVISION OF BASIC SCIENCES - | Dev Procure