grant
Design and Synthesis of Novel Action Inhibitors for Bruton's Tyrosine Kinase (BTK)
Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
Description preview
Bruton's Tyrosine Kinase (BTK) has a pivotal role in the BCR signalling pathway which is upregulated in B cell malignancies. Activation is dependent on two phosphorylation events, at Y551 and Y223 in the kinase and SH3 domains respectively. Of the remaining three domains, the Pleckstrin Homology (PH) domain is essential for the membrane…
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