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Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway

Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Jan 2021Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY20252-photonAcousticsActive ListeningAddressAnatomic SitesAnatomic structuresAnatomyAnesthesiaAnesthesia proceduresAnimalsApicalAuditoryAuditory CortexAuditory areaAuditory systemBehavioralBehavioral AssayBiophysical ProcessBrainBrain Nervous SystemBrain StemBrainstemCell Communication and SignalingCell SignalingCognitionCognitiveCognitive DiscriminationComplexDataDendritesDetectionDiscriminationEncephalonEpidemicEventFeedbackFrequenciesGenerationsGlutamatesGoalsHeadHearingHearing DisordersHearing LossHearing problemHypoacusesHypoacusisImageIn VitroInferior ColliculusIntracellular Communication and SignalingKnowledgeL-GlutamateLearningLightLinguisticLinguisticsLinkMediatingMesencephalonMiceMice MammalsMid-brainMidbrainMidbrain structureMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNoise-Induced Hearing LossOutcomeOutputPathway interactionsPerceptionPerceptual learningPhotoradiationPlayPosterior Quadrigeminal BodyPresbyacusisPresbycusisPublic HealthQOL improvementRewardsRinging-Buzzing-TinnitusRoleSensoryShapesSignal TransductionSignal Transduction SystemsSignalingSpeechStimulusStreamSynapsesSynapticTestingTimeTinnitusTransmissionWorkage associated hearing lossage induced hearing lossage related decline in hearingage related hearing deficitsage related hearing impairmentage related hearing lossaging associated hearing lossaging induced hearing lossaging related decline in hearingaging related hearing deficitsaging related hearing impairmentaging related hearing lossauditory discriminationauditory diseaseauditory disorderauditory dysfunctionauditory pathwayauditory problemauditory processingawakebiological signal transductionbiophysical mechanismdiscrimination taskdysfunctional hearingexperienceexperimentexperimental researchexperimental studyexperimentsglutamatergichearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing discriminationhearing diseasehearing dysfunctionhearing impairmentimagingimprovements in QOLimprovements in quality of lifeneural cell bodyneuronalneuronal cell bodynew approachesnoise related hearing lossnoise-induced hearing impairmentnovel approachesnovel strategiesnovel strategyoperationoperationsoptogeneticspathwayphysical propertypreventpreventingquality of life improvementsegregationsensory systemsocial rolesomasoundsynapsetransmission processtwo-photon

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Project Summary/Abstract
Active listening is central to auditory cognition, supporting critical functions such as stream segregation,

linguistic analysis and perceptual learning. To this end, the brain must accurately represent the physical

properties of acoustic signals and subsequently parse sounds based on their behavioral relevance. Whereas…

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