grant
Degradomics of proteolytic mechanisms in post-traumatic osteoarthritis
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 22 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025ACL injuryADAMTSAcuteAddressAminesBiological MarkersBloodBlood Reticuloendothelial SystemBody TissuesBone InflammationBone remodelingCartilageCartilaginous TissueCatabolismCell BodyCell-Extracellular MatrixCellsChymaseClinicalClinical ManagementCodeCoding SystemCommunitiesCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDataDegenerative ArthritisDegenerative polyarthritisDetectionDiagnosisDimensionsDiseaseDisease Frequency SurveysDisease PathwayDisorderDomestic HorseDrug TargetingDrugsECMEarly DiagnosisEarly identificationEarly treatmentEnzyme GeneEnzymesEquineEquine SpeciesEquus caballusEquus przewalskiiEsteroproteasesEventExtracellular MatrixFailureFutureGoalsHorsesHumanImmuneImmunesIndividualInflammationInjuryIsotope LabelingJointsKnee OsteoarthritisKnowledgeLibrariesLiquid substanceMMCP-1MMP-13MMP-13 gene productMMP13 gene productMarrow Mast CellMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMeasuresMechanicsMediatingMedicationMedicineMethodsModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMultivariate AnalysesMultivariate AnalysisOsteitisOsteoarthritisOsteoarthrosisOutcomePainPainfulPathogenicityPathway interactionsPatientsPeptidasesPeptide HydrolasesPeptidesPersonalized medical approachPersonsPharmaceutical PreparationsPhasePilot ProjectsPrevalenceProcessProtease GeneProteasesProtein CleavageProteinasesProteinsProteolysisProteolytic EnzymesProteomeProteomicsResearchResearch MethodologyResearch MethodsRiskRisk AssessmentRoleSamplingSynoviaSynovial FluidSystems BiologyTechnologyTimeTissue BasophilsTissuesTraumatic ArthritisTraumatic ArthropathyWorkamineanalyzing longitudinalanterior cruciate ligament injuryarticular cartilagebio-markersbiologic markerbiomarkerbiomarker developmentcell typechymase-1chymotrypsin-like proteaseclotting enzymecollagenase 3data librarydata sharing networksdata sharing resourcedefined contributiondegenerative joint diseasediagnostic biomarkerdiagnostic markerdrug developmentdrug/agentearly biomarkersearly detectionearly detection biomarkersearly detection markersearly therapyfluidfuture epidemicglobal healthhigh riskhypertrophic arthritisimprovedindividualized approachinflamed boneinjuriesinnovateinnovationinnovativeinsightinterestinternet resourcejoint damagejoint functionjoint injuryjoint traumaknee OAknee joint OAknee joint osteoarthritisliquidlongitudinal analysismast cellmast cell proteasemast cell protease 1mast cell protease Imast cell proteinase-1mastocytematrix metalloproteinase-13mechanicmechanicalmolecular profilemolecular signaturenew drug treatmentsnew drugsnew pharmacological therapeuticnew technologynew therapeuticsnew therapynext epidemicnext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel technologiesnovel therapeuticsnovel therapyon-line compendiumon-line resourceonline compendiumonline resourcepathwaypersonalized approachpilot studypost-traumatic osteoarthritisprecision approachresearch and methodsskeletal muscle proteasesocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicssubchondral bonetailored approachtimelineweb resourceweb-based resourceyounger age
Description preview
Osteoarthritis (OA) is usually diagnosed when joint damage is well under way. Its early detection and treatment
continue to be elusive, requiring greater knowledge of pathogenic processes and potential drug targets active
early in the disease. Proteolytic destruction of cartilage extracellular matrix (ECM) is a hallmark of OA that
contributes to…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click