grant
Defining the role of Tox3 in congenital cerebellar hypoplasia and ataxia
Organization CEDARS-SINAI MEDICAL CENTERLocation LOS ANGELES, UNITED STATESPosted 15 Jul 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ACTL6BACTL6B geneAD/HDADHDASDATAC sequencingATAC-seqATACseqAblationAcuteAnatomic SitesAnatomic structuresAnatomyAssay for Transposase-Accessible Chromatin using sequencingAtaxiaAtaxyAttention deficit hyperactivity disorderAutismAutistic DisorderBAF53BBasal Transcription FactorBasal transcription factor genesBiologic ModelsBiological ModelsBody TissuesBrainBrain CancerBrain DiseasesBrain DisordersBrain Nervous SystemBrain regionBreast CancerCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCUT&RUNCalcium Ion SignalingCalcium SignalingCancersCell BodyCell Communication and SignalingCell Fate ControlCell Fate RegulationCell SignalingCellsCerebellar AtaxiaCerebellar DiseasesCerebellar DisordersCerebellar DysfunctionCerebellar IncoordinationCerebellar SyndromesCerebellar hypoplasiaCerebellumCerebellum DiseasesChemical FractionationChildhoodChromiumCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCognitionCognitiveComplementComplement ProteinsCongenital cerebellar hypoplasiaCoordination ImpairmentCoupledCr elementDA NeuronDNA Binding DomainDNA-Binding Protein MotifsDataDevelopmentDiseaseDisorderDopamine neuronDysfunctionDyslexiaDyssynergiaEarly Infantile AutismEkbom SyndromeElectroporationElementsEmbryoEmbryonicEmotionsEncephalonEncephalon DiseasesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumFRACNFamilyFore-BrainForebrainFourth VentricleFourth Ventricle of the BrainFourth ventricle structureFractionationFractionation RadiotherapyFunctional disorderGWA studyGWASGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGeneticGenetics-MutagenesisGestationGoalsHistonesHumanImageImmune systemIn VitroInfantile AutismIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigationKO miceKanner's SyndromeKnock-outKnock-out MiceKnockoutKnockout MiceLabelLanguageLightLipLip structureLong-term infectionMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMapsMediatingMethodsMiceMice MammalsModel SystemModern ManMolecularMotorMovementMulticellular Developmental ProcessMurineMusMutagenesisMutagenesis Molecular BiologyNerve CellsNerve UnitNervous SystemNeural CellNeural Stem CellNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNull MouseParalysis AgitansParkinsonParkinson DiseasePathologicPathologyPatternPhenotypePhotoradiationPhysiopathologyPopulationPredispositionPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPregnancyPrimary ParkinsonismPrimordiumProcessProsencephalonProtein FamilyProteinsRegulationRepressionResearchRestless LegsRestless Legs SyndromeRoleSatiationSignal TransductionSignal Transduction SystemsSignalingSiteSpecific qualifier valueSpecifiedStructureSubstantia NigraSubstantia nigra structureSusceptibilityT-CellsT-LymphocyteT8 CellsT8 LymphocytesTamoxifenTimeTissue Development ProcessTissuesTitrationsTranscription Factor Proto-OncogeneTranscription factor genesVentricularWord BlindnessWorkactin-like 6Bassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingautism spectral disorderautism spectrum disorderautistic spectrum disorderbalancebalance functionbiological signal transductionbody movementcell typechromatin remodelingchronic infectioncognitive functioncompare to controlcomparison controlcomplementationconditional knock-outconditional knockoutdevelopmentaldevelopmental diseasedevelopmental disorderdopaminergic neuronelectroporative deliveryepigenetic regulationepigeneticallyexhaustionfrontal cortexfrontal lobegene electrotransfergene networkgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygranule cellhistogenesishuman diseaseimagingin vivoinsightmalignancymalignant breast tumormembermotor controlmouse modelmulti-modalitymultimodalitymultiomicsmultiple omicsmurine modelmutantneoplasm/cancernerve stem cellnestinnestin proteinneuralneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornotchnotch proteinnotch receptorsnovelpanomicspars compactapathophysiologypediatricpersistent infectionprecursor cellprogenitor and neural stem cellssatietyscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolespatial and temporalspatial memoryspatial temporalspatiotemporalthymus derived lymphocytetranscription factortranscriptomicsvirtualwhole genome association analysiswhole genome association study
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PROJECT SUMMARY / ABSTRACT
The cerebellum is an exquisitely laminated structure regulating balance, voluntary motor coordination and
modulating language and cognition through connections with the forebrain. Sitting just under the forebrain, the
cerebellum is estimated to contain roughly 80% of the neurons in the human brain. Accordingly,…
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