grant
Defining the role of antigen-specific T cell responses in NASH
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 4 Feb 2026Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2026Adaptive Immune SystemAddressAffectAlcohol DrinkingAlcohol consumptionAllelesAllelomorphsAnimal Disease ModelsAntigen PresentationAntigen-Presenting CellsAntigenic DeterminantsAntigensAutoantigensAutoimmuneAutologous AntigensAutomobile DrivingAutoregulationBinding DeterminantsCAR T cell therapyCAR T cellsCAR T therapyCAR modified T cellsCAR-TCAR-TsCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell BodyCellsCellular biologyCessation of lifeChronicCirrhosisClonal ExpansionCollectionComplementComplement ProteinsDataDeathDendritic CellsDietDiseaseDisease ProgressionDisorderEpidemicEpitopesEtOH drinkingEtOH useEventFibrosisGoalsGrafting ProcedureHLA-AHLA-A geneHLA-BHLA-B AntigensHLAAHepatic DisorderHepatic TransplantationHomeostasisHumanImmuneImmunesIncidenceIndividualInflammationInnate Immune SystemKineticsLife Style ModificationLinkLiteratureLiverLiver GraftingLiver TransplantLiver diseasesMacrophageMacrophage ActivationMetabolic dysfunctionMethodologyMiceMice MammalsModelingModern ManMorbidityMurineMusMyeloid CellsMφNASHObesityOrgan TransplantationOrgan TransplantsPathogenesisPathogenicityPathologyPatientsPeptidesPersonsPhysiological HomeostasisPolymorphism AnalysisPolymorphism DetectionPopulationPreventionProcessProliferatingPublicationsPublishingReportingResearchResolutionRoleScientific PublicationSelf-AntigensShapesSingle cell seqSocietiesSteatohepatitisT cell responseT cells for CART-Cell ActivationT-CellsT-LymphocyteT8 CellsT8 LymphocytesTherapeutic InterventionUnited StatesVeiled CellsViral DiseasesVirus Diseasesaccessory cellacquired immune systemactivate T cellsadaptive immune responseadiposityalcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakeantigen-specific T cellsburden of diseaseburden of illnesscell biologychimeric antigen T cell receptorchimeric antigen receptor (CAR) T cell therapychimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cell therapychimeric antigen receptor T cellschimeric antigen receptor T therapychimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellschronic hepatic diseasechronic hepatic disorderchronic liver diseasechronic liver disordercirrhoticcohortcomplementationconflict resolutioncorpulencecytokinecytotoxicdiet-associated obesitydiet-induced obesitydiet-related obesitydietsdisease burdendisease modeldisorder modeldraining lymph nodedrivingeffective therapyeffective treatmentethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol usehepatic body systemhepatic diseasehepatic organ systemhepatopathyimmunogenintervention therapylifestyle modificationliver disorderliver transplantationmigrationmortalitymouse modelmurine modelnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnon-alcohol induced steatohepatitisnon-alcoholic steato-hepatitisnon-alcoholic steatohepatitisnonalcoholic steato-hepatitisnonalcoholic steatohepatitisnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetorgan allograftorgan graftorgan xenograftpreventpreventingprogramsrecruitregional lymph noderesolutionsresponsesingle cell next generation sequencingsingle cell sequencingsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetoolviral infectionvirus infectionvirus-induced disease
Description preview
Project Summary
Chronic liver diseases are a collection of disorders that result in significant morbidity and mortality worldwide.
The overwhelming burden of these diseases results in the liver being the second most transplanted organ. As
a result of a dramatic rise in the incidence of obesity and alcohol consumption, the rate of liver…
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