grant
Defining the Role of Angiotensin II Type 2 Receptor in Bladder Physiology and Pathophysiology with Mouse Models
Organization MEDICAL COLLEGE OF WISCONSINLocation MILWAUKEE, UNITED STATESPosted 13 Feb 2026Deadline 12 Feb 2028
NIHUS FederalResearch GrantFY2026AbdomenAddressAdverse effectsAgonistAngIIAngiotensin AT1 ReceptorAngiotensin AT2 ReceptorAngiotensin IIAngiotensin II ReceptorAngiotensin II Type 1 ReceptorAngiotensin II Type 1 Receptor AntagonistsAngiotensin II Type 1 Receptor BlockersAngiotensin Receptor 2Angiotensin-Forming EnzymeAngiotensinogenaseAngiotensinsAssayAttenuatedAutoimmuneBP homeostasisBP regulationBehavioralBioassayBiological AssayBiomedical EngineeringBladderBladder DiseasesBladder DisorderBladder DysfunctionBladder TissueBladder Urinary SystemBody SystemC57BL/6 MouseCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell Communication and SignalingCell SignalingChronicClinicalCommunicationComplexComplex thinkingContracting OpportunitiesContractsCritical ThinkingCystitisDataDiseaseDisorderDrug TargetingDrug TherapyDysfunctionEquilibriumEvaluationEvaluative ThinkingFellowshipFemaleFoundationsFunctional disorderFutureGoalsHeart VascularHigh PrevalenceHyperalgesiaHyperalgesic SensationsHypersensitivityIncreased frequency of micturitionInflammationInterstitial CystitisIntracellular Communication and SignalingInvestigationJointsKidneyKidney Urinary SystemKnowledgeLeadLifeLiteratureLocationMediatingMentorshipMessenger RNAMiceMice MammalsModelingMolecularMurineMusNon-pharmacologic TherapyNonpharmacologic InterventionNonpharmacologic TherapyNonpharmacologic approachNonpharmacologic treatmentOrgan SystemPathologicPathologyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPb elementPelvicPelvic RegionPelvisPh D studentPh D. studentPh. D. studentPh.D studentPh.D. studentPhD studentPhD. studentPharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPhysiologyPhysiopathologyPlayPreparationPropertyQOLQuality of lifeRT-PCRReceptor ActivationReceptor ProteinReceptor, Angiotensin, Type 1ReninRenin-Angiotensin SystemResearchReverse Transcriptase Polymerase Chain ReactionRoleScienceScientistSignal TransductionSignal Transduction SystemsSignalingSystemTechnical ExpertiseTestingTherapeuticType 1 Angiotensin Receptor AntagonistsType 1 Angiotensin Receptor BlockersType 2 Angiotensin II ReceptorUniversitiesUrinary FrequencyUrotheliumVasodilatationVasodilationVasorelaxationWisconsinWorkangiotensin II type I receptorangiotensin type 2 receptorattenuateattenuatesbalancebalance functionbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionbladder pain syndromeblood pressure homeostasisblood pressure regulationcareercell typecirculatory systemdoctoral studentdrug interventiondrug treatmentexperimentexperimental researchexperimental studyexperimentsheavy metal Pbheavy metal leadhyperalgiaimprovedin vivoinnovateinnovationinnovativemRNAmRNA Expressionmalemedical collegemedical schoolsmouse modelmurine modelnon-drug therapynon-drug treatmentnondrug therapynondrug treatmentnovelpainful bladder syndromepathophysiologypatient oriented outcomespharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreparationsprotective effectreceptorreceptor expressionregulate BPregulate blood pressurerenalresponsereverse transcriptase PCRschool of medicinesocial rolesubcutaneoussubdermaltechnical skillstherapeutic targettoolurinary bladderurinary bladder disordervascular constrictionvasoconstriction♀♂
Description preview
PROJECT SUMMARY
The complex communication mechanisms involved in bladder function are not fully understood. Due to this lack
of physiological understanding, bladder diseases have remained challenging to treat, resulting in severe
detriment to patient quality of life, particularly in the case of interstitial cystitis/bladder pain syndrome (IC/BPS).…
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