grant
Defining the molecular determinants of inflammatory memory in the pancreas
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AP-1AP-1 Enhancer-Binding ProteinAP1AP1 proteinAblationAcinar CellAciner CellsActivator Protein-1AcuteAddressAffectAmnesiaAmnesia-Memory LossArticulationAttenuatedAutoimmune DiseasesAutomobile DrivingAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBody TissuesCaeruleinCancersCell BodyCell Communication and SignalingCell CompartmentationCell CompartmentationsCell SignalingCellsCeruletidCeruletideChromatinChronicCommunicable DiseasesDNA mutationDataDepositDepositionDevelopmentDuctDuct (organ) structureEnhancer-Binding Protein AP1EnhancersEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsExtracellular Signal-Regulated Kinase GeneFRAsFos-Related AntigensFutureGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsHeterogeneityHistologicHistologicallyHomeostasisImmuneImmunesInfectious DiseasesInfectious DisorderInflammationInflammation MediatorsInflammatoryInjuryIntracellular Communication and SignalingIsoformsKRAS driven oncogenesisKRAS oncogenesisKRAS-driven tumorigenesisKRAS-mediated tumorigenesisLineage TracingMAP Kinase GeneMAPKMAPK Signaling PathwayMAPK Signaling Pathway PathwayMEKsMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMediatingMemoryMetaplasiaMetaplastic ChangeMiceMice MammalsMitogen-Activated Protein Kinase GeneMolecularMolecular InteractionMurineMusMutationNatural regenerationNuclearOncogenesisOncogenicOrganoidsPancreasPancreas CancerPancreaticPancreatic CancerPancreatitisPathway interactionsPatientsPhasePhenotypePhosphorylationPhysiological HomeostasisProtein IsoformsProtein PhosphorylationRNA ExpressionRecombinantsRegenerationResearchResolutionRisk FactorsRoleSecondary toShapesSignal TransductionSignal Transduction SystemsSignalingStimulusStressTherapeuticTimeTissue PreservationTissuesTranscriptionTranscription AlterationTranscription Factor AP-1Transcription Factor Proto-OncogeneTranscription factor genesUpregulationWorkairway epithelial stem cellsairway progenitorairway stem cellsattenuateattenuatesautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductionbiological systemscancer microenvironmentcancer riskcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingchronic inflammatory diseasecytokinedevelopmentaldrivingepigenetic memoryepigeneticallyepigenomeepigenomicsepithelial progenitorepithelial progenitor cellepithelial stem cellexperiencegenome mutationhuman diseasein vivoinflammatory mediatorinhibitorinjuriesinjury responselong-term sequelaemalignancymouse modelmurine modelmutantneoplasm/canceroncogenic KRASpancreas developmentpancreatic malignancypathwaypharmacologicregenerateresolutionsrespiratory progenitorrespiratory stem cellresponseresponse to injurysocial rolestem cells in the airwaysynergismtooltranscription factortumor initiationtumor microenvironmenttumorigenesis
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Project Summary / Abstract
Biological systems operate within fluctuating environments, and, therefore, are inherently tasked with accurately
responding in real-time to a myriad of signals. Recent evidence suggests that a memory of inflammation can be
encoded and retained in the epigenome of cells even following resolution of the initial stimulus.…
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