grant
Defining Ocular Monkey Pox Pathogenic Mechanisms
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025(TNF)-αAgonistAnimal ModelAnimal Models and Related StudiesAnti-viral AgentsAnti-viral ResponseAnti-viral TherapyAreaB220Beta Proprotein Interleukin 1BlepharitisBody TissuesCCL5CD45CRG-2CXCL10CXCL10 geneCachectinCell BodyCell Communication and SignalingCell Culture TechniquesCell DeathCell SignalingCell surfaceCellsCellular TropismCessation of lifeChemokine (C-C Motif) Ligand 5ConjunctivitisCorneaCorneal OpacityCorneal UlcerCytoplasmD17S136EDNADNA mutationDataDeathDeoxyribonucleic AcidDetectionDevelopmentDiminished VisionDisease OutbreaksEndogenous Interferon BetaEpithelial CellsEvolutionExanthemExanthemaExhibitsExtremitiesEyeEye InfectionsEyeballFLJ11330FaceFibroblast InterferonGP180Gene variantGeneralized GrowthGenesGenetic ChangeGenetic defectGenetic mutationGenital OrgansGenitaliaGenomicsGoalsGrowthHumanIFI10IFNIFN-regulatory factor 3IFN-βIFNbIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βINP10IP-10IRF-3 proteinIRF3IRF3 geneImmuneImmune responseImmunesIn VitroInfectionInfiltrationInflammationInflammatoryInflammatory ResponseInnate Immune ResponseInnate Immune SystemInterferon Regulatory Factor 3Interferon Type IInterferon-βInterferonsInterleukin 1betaInterleukin-1 betaInterleukin-1βIntracellular Communication and SignalingKeratitisKinasesKineticsLY5LeftLesionLeukomaLibrariesLimb structureLimbsLow VisionMGC17164MOB-1Macrophage-Derived TNFMiceMice MammalsModern ManMonkey PoxMonkey Pox VirusMonkeypoxMonkeypox virusMonkeypoxvirusMonocyte-Derived TNFMorbidityMorbidity - disease rateMurineMusMutationNF-Kb-Activating Kinase GeneNatural Interferon BetaNatural human interferon betaNon-Polyadenylated RNANon-TrunkOcular InfectionsOcular PathologyOutbreaksOutcome MeasurePTPRCPTPRC genePainPainfulPartial SightPathogenesisPathogenicityPathologicPathway interactionsPhosphoproteinsPhosphotransferase GenePhosphotransferasesPredispositionPreinterleukin 1 BetaProcessProcidentiaProlapseProteinsPtosisRANTESRNARNA Gene ProductsRashRecombinantsReduced VisionReproducibilityResearchRibonucleic AcidRoleRouteSCYA5SCYB10SIS deltaSIS-deltaSISdSeveritiesSightSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkin RashSmall Inducible Cytokine A5Stimulator of Interferon GenesSubnormal VisionSusceptibilityT-Cell RANTES ProteinT-Cell Specific Protein p288T200T2KTBK1TBK1 geneTCP228TNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTissue GrowthTissuesTransmissionTransphosphorylasesTumor Necrosis FactorTumor Necrosis Factor-alphaUlcerative KeratitisUnited StatesViralViral BurdenViral DiseasesViral GenesViral GenomeViral LoadViral Load resultVirusVirus DiseasesVirus ReplicationVisionVisual impairmentZoonosesZoonoticZoonotic Infectionallelic variantanti-viral compoundanti-viral developmentanti-viral drug developmentanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viral therapeutic developmentanti-viral therapy developmentanti-viralsantiviral developmentantiviral drug developmentantiviral therapeutic developmentantiviral therapy developmentbiological signal transductioncGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcell culturecell culturescell typecicatrix cornealcornea opacitycornea ulcercornealcorneal epithelialcorneal epitheliumcorneal fibrosiscorneal scarcorneal ulcerationcyclic GMP-AMP synthase/STINGcytokinedesigndesigningdeveloping anti-viral agentdeveloping anti-viral drugdeveloping anti-viral therapeuticdeveloping anti-viral therapydeveloping antiviral agentdeveloping antiviral drugdeveloping antiviral therapeuticdeveloping antiviral therapydevelopmentalefficacy testingextracellularfacesfacialfitnessgIP-10genetic variantgenome mutationgenomic varianthost responseimmune system responseimmunoresponseinjury to tissueinnate immune pathwaysinsightkinase inhibitormeasurable outcomemodel of animalmouse modelmpoxmpox virusmpxvmurine modelmutantnecrocytosisnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetocular surfaceontogenyoutcome measurementparticlepathogenpathwayrespiratoryresponsescreeningscreeningssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstherapeutic targettissue injurytransmission processviral infectionviral infectious disease treatmentviral multiplicationviral replicationvirus genomevirus infectionvirus multiplicationvirus-induced diseasevision impairmentvisual functionvisually impaired
Description preview
PROJECT SUMMARY:
Mpox virus (MPXV), formerly Monkeypox virus is a zoonotic pathogen that spreads rapidly through human-
human transmission via respiratory droplets and direct contact, causing painful rashes and systemic issues. It
also causes moderate to severe ophthalmic manifestations, most commonly ocular surface complications such
as…
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