grant
Defining Genome Stability Mechanisms and their Regulation by SUMO and Ubiquitin
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 1 Sept 2020Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAPF-1ATP-Dependent Proteolysis Factor 1Acute Promyelocytic LeukemiaApoptosisApoptosis PathwayArsenic (III) OxideArsenic SesquioxideArsenic TrioxideArsenous Acid AnhydrideArsenous OxideBasic Mechanisms of SUMOylationBindingBinding ProteinsBiochemicalBiologicalCancersCell BodyCell Communication and SignalingCell SignalingCellsChimera ProteinChimeric ProteinsChromatinChromosomesCircular DNAComplexDNA DamageDNA InjuryDiseaseDisorderDisparateE3 LigaseE3 Ubiquitin LigaseEnvironmentEnzyme GeneEnzymesFusion ProteinGene Down-RegulationGeneticGenetic screening methodGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityGoalsHMG-20HealthHigh Mobility Protein 20Intracellular Communication and SignalingKnowledgeL-LysineLabelLigand Binding ProteinLigand Binding Protein GeneLysineMacropainMacroxyproteinaseMaintenanceMalignant CellMalignant NeoplasmsMalignant TumorMapsMediatingMethodsMolecular InteractionMulticatalytic ProteinaseMyeloid Leukemia, Acute, M3OncogenicPML nuclear bodiesPML-RARAPML-RARalphaPML-RARalpha proteinPML-RARαPathway interactionsPhasePlasmidsPlayProcessProgrammed Cell DeathProgranulocytic LeukemiaProsomeProteasomeProteasome Endopeptidase ComplexProtein BindingProteinsProteomicsProteosomeRegulationRepressionSUMOylationSignal TransductionSignal Transduction SystemsSignalingSiteSpecificitySumoylation PathwayTherapeuticTherapeutic EffectTherapeutic InterventionTranscription RepressionUbiquitinUbiquitin Ligase Component GeneUbiquitin Ligase GeneUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3ViralViral DiseasesVirus DiseasesVirus ReplicationWhite Arsenicarsenous anhydridebiologicbiological signal transductionbound proteincancer cellcofactorcohesincondensindiarsenic trioxidefightinggene repressioninsightintervention therapymalignancymulticatalytic endopeptidase complexneoplasm/cancernovelp97 ATPasepathogenic viruspathwaypreventpreventingpromyelocytic leukemiapromyelocytic leukemia nuclear bodiesprotein complexprotein functionresponsesynergismtelomereubiquitin ligaseubiquitin-protein ligaseviral infectionviral multiplicationviral pathogenviral replicationvirus infectionvirus multiplicationvirus pathogenvirus-induced disease
Description preview
The overarching goal of our proposal is to define how the posttranslational modifiers (PTMs) SUMO and ubiquitin
orchestrate diverse cellular pathways that prevent genome instability, fight viral infections, and maintain cellular
health. Both PTMs are covalently attached to lysine residues by a cascade consisting of E1/E2 enzymes, and
E3 ligases,…
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