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Defining functional humoral correlates of immunity to guide vaccine design
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 24 Nov 2020Deadline 31 Oct 2025 ⚠️
NIHUS FederalResearch GrantFY20250-11 years oldAb responseAb-mediated immunityAb-mediated protectionActive Follow-upAffinityAfricanAnti-malarialsAntibodiesAntibody FormationAntibody ProductionAntibody immunityAntibody protectionAntibody-mediated protectionAntigen TargetingAntigensBindingBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood group antigen SCell BodyCell Mediated ImmunologyCell-Mediated ImmunityCellsCellular ImmunityCessation of lifeChildChild YouthChildren (0-21)ClinicalClinical Treatment MoabComplementComplement ProteinsComplement ReceptorComplexCytotoxic cellDataDeathDevelopmentDiseaseDisorderDissectionDrug resistanceEffector CellFc ReceptorGroups at riskHepaticHumanImmuneImmune responseImmunesImmunityImmunizationIn VitroIndividualInfantInfectionInfection preventionInnate Immune SystemInsecticidesK lymphocyteKnowledgeLiverMacrophageMalariaMalaria VaccinesMalarial VaccinesMarrow NeutrophilMediatingModelingModern ManMolecular InteractionMonoclonal AntibodiesMosquito ControlMosquito-borne diseaseMosquito-borne infectious diseaseMφNK CellsNatural Killer CellsNatureNeutrophilic GranulocyteNeutrophilic LeukocytePaludismParasite resistanceParasitesPatternPeople at riskPersons at riskPhagocytosisPlasmodiumPlasmodium InfectionsPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulations at RiskPrevent infectionRoleS antigenSamplingSerologyShapesSpecificitySporozoite vaccineSporozoitesSystemVaccinationVaccination acquired immunityVaccination induced immunityVaccine DesignVaccineeVaccinesactive followupanti-malarial agentsanti-malarial drugsanti-microbialantibody biosynthesisantibody receptorantibody-mediated immunityantimicrobialcomplementationdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldisease riskdisorder riskdrug distributiondrug resistantefficacy studyevaluate vaccinesfield based datafield learningfield studyfield testfollow upfollow-upfollowed upfollowuphepatic body systemhepatic organ systemhost responseimmune response to vaccinationimmune response to vaccinesimmune system responseimmunogenimmunoglobulin biosynthesisimmunoresponseinsightkidsmAbsmalaria infectionmalaria-infectedmalarial infectionmonoclonal Absmortalityneutrophilnew vaccinesnext generationnext generation vaccinesnovelnovel vaccinesparasite resistantpathogenphase 2 trialphase 3 trialphase II trialphase III trialprogramsrecruitresistance in parasiteresistance to Drugresistance to Parasiteresistant parasiteresistant to Drugresistant to Parasiteresponsesocial rolesynergismvaccinated individualvaccinated participantvaccinated patientvaccinated personvaccinated subjectvaccination studyvaccination trialvaccine acquired immunityvaccine associated immune responsevaccine associated immunityvaccine developmentvaccine evaluationvaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine platformvaccine responsevaccine responsivenessvaccine screeningvaccine studyvaccine testingvaccine trialvaccine-induced immunityvaccine-induced protectionvaccine-induced responsevaccines against malariayoungster
Applications closed.
Description preview
Malaria, a mosquito-borne disease caused by Plasmodium spp., was responsible for nearly half a million deaths
in 2017, with an additional 3.2 billion people at risk of disease. While aggressive insecticide-treated bed-net
distribution, mosquito control, and anti-malarial drug distribution programs have significantly reduced mortality
associated…
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