grant
Defining Characteristics of a Resilient Organelle Interactome During Aging
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAI basedAffectAgeAge of OnsetAgingAnimalsArchitectureAtlasesAutomobile DrivingAutoregulationBiologyBiology of AgingC elegansC. elegansC.elegansCaenorhabditis elegansCatalogingCell AgingCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SenescenceCell ShapeCell SignalingCellsCellular AgingCellular FunctionCellular PhysiologyCellular ProcessCellular SenescenceCellular biologyCharacteristicsChronic DiseaseChronic IllnessClassificationCommunitiesCustomDataDeteriorationDimensionsDiseaseDisorderDissectionDysfunctionElectron MicroscopyEndoplasmic ReticulumEngineering / ArchitectureEpidermisErgastoplasmEventFailureFunctional disorderFutureGeneticHealthHomeostasisImage AnalysesImage AnalysisIndividualIntermediary MetabolismInterventionIntestinalIntestinesIntracellular Communication and SignalingInvestigationIonsLeannessLength of LifeLifeLinkLipidsLongevityLysosomesMapsMembraneMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismMitochondriaModelingMolecularMorphologyMuscleMuscle TissueNerve CellsNerve UnitNeural CellNeurocyteNeuronsOrganellesOrganismPathogenicityPathologyPatternPerformancePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlayPropertyProteomicsPublic HealthRegulationReplicative SenescenceReportingResearchRisk FactorsRoleScanning Electron MicroscopyShapesSignal TransductionSignal Transduction SystemsSignalingSiteStressSubcellular ProcessSumSystemSystematicsTestingThinnessTrainingVisualizationWorkage associatedage associated alterationsage associated changesage associated diseaseage associated disorderage associated impairmentage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent diseaseage dependent disorderage dependent impairmentage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related human diseaseage related pathwaysage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentagedaged animalaged animalsagesaging associated alterationsaging associated changesaging associated mechanismaging correlated alterationsaging correlated changesaging delayaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging mechanismaging pathwayaging processaging related alterationsaging related changesaging related mechanismaging related pathwaysaging resilienceaging specific alterationsaging specific changesalterations with ageanimal old ageartificial intelligence basedattenuate agingbiological adaptation to stressbiological mechanism of agebiological pathways of agebiological signal transductionbowelbuild resiliencebuild resiliencycell biologycell typechanges with agechronic disordercustomsdecelerate agingdeep learningdeep learning methoddeep learning strategydelay age relateddevelop resiliencedevelop resiliencydietary restrictiondrivers of agingdrivingelderly animalenhance resilienceenhance resiliencyfacilitate resiliencefat metabolismfrontiergerodriverhealthy aginghealthy human agingimage evaluationimage interpretationimprove resilienceimprove resiliencyin vivoincrease resilienceincrease resiliencyinsightinsulin signalingintervention enhancing longevityintervention to extend lifespanintervention to improve lifespanintervention to increase longevityintervention to prolong lifespanintervention to promote longevitylifespan extending interventionlifespan extending therapieslifespan improving interventionlifespan increasing interventionlifespan increasing therapieslifespan interventionlifespan prolonging interventionslifespan promoting interventionlipid metabolismliving systemlongevity boosting interventionlongevity extending interventionlongevity interventionlongevity promoting interventionlongevity therapylongevity treatmentmechanism regulating agingmechanisms involved in agingmembrane structuremitochondrialmodel organismmortalitymuscularmutantneuronalnovelold animalspathophysiologypathway involved in agingpause agingpostpone age relatedpreventpreventingpromote resiliencepromote resiliencyreaction; crisisreplicative agingresilienceresilience developmentresilience during agingresilience in agingresilience in normal agingresilience to agingresilience with agingresilientresilient agingresilient to agingresponserestricted dietretards agingslow agingslow down agingslow the rate of agingsocial rolespatial relationshipstrategy to enhance longevitystrategy to promote longevitystress responsestress; reactionthree dimensionaltooltranscriptomics
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Project Summary
A growing body of work suggests that aging is not simply the sum of molecular damage, but a systems-level
shift in cell physiology—one that compromises resilience, rewires metabolism, and alters the cell’s capacity to
adapt to stress. Yet despite deep insight into the aging process from transcriptomic and proteomic profiling, a…
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