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Defining a novel protein network for Toxoplasma repurposing of host ESCRT machinery
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 4 Jan 2024Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteBindingBiologyBipolar Affective PsychosisBipolar DisorderBlindnessBody TissuesCRISPR approachCRISPR based approachCRISPR editing screenCRISPR methodCRISPR methodologyCRISPR screenCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based screenCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 screenCRISPR/Cas9 technologyCancersCas nuclease technologyCell BodyCell FunctionCell PhysiologyCell ProcessCell divisionCell to Cell Communication and SignalingCell-Cell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsComplexCoupledCytoplasmCytosolDeveloping fetusDiseaseDisorderEndosomesEnsureEnvironmentFetal DevelopmentGeneralized GrowthGenetic ScreeningGoalsGrafting ProcedureGroups at riskGrowthHIVHealthHomolog of Yeast Vacuolar Protein Sorting 23HumanHuman Immunodeficiency VirusesHypothetical ProteinImageImage AnalysesImage AnalysisImmune EvasionIndividualInfectionIngestionInnate ImmunityKinasesKnowledgeLAV-HTLV-IIILinkLipidsLymphadenopathy-Associated VirusMachine LearningMaintenanceMalignant NeoplasmsMalignant TumorManic-Depressive PsychosisMediatingMembraneMental disordersMental health disordersMetabolic Protein DegradationMiceMice MammalsModern ManMolecular InteractionMultivesicular BodyMurineMusNative ImmunityNatural ImmunityNervous System InjuriesNervous System TraumaNervous System damageNeurological DamageNeurological InjuryNeurological traumaNon-Specific ImmunityNonspecific ImmunityNuclear EnvelopeNuclear MembraneNutrientOrganOrgan TransplantationOrgan TransplantsOrganellesParasitesPathogenicity FactorsPeople at riskPersons at riskPhenotypePhosphorylationPhosphotransferase GenePhosphotransferasesPlayPopulations at RiskProtein PhosphorylationProtein TurnoverProteinsPsychiatric DiseasePsychiatric DisorderReceptosomesRegulatory Protein DegradationReportingResearchResearch ResourcesResidualResidual stateResourcesRisk FactorsRoleSchizophreniaSchizophrenic DisordersSeriesSortingStructureSubcellular ProcessSystemT gondiiT gondii infectionT. gondiiT. gondii infectionTSG101TSG101 geneTestingTissue GrowthTissuesToxoplasmaToxoplasma gondiiToxoplasma gondii InfectionToxoplasmosisTransphosphorylasesVPS23VacuoleVertebrate AnimalsVertebratesVesicleVirulence FactorsVirus-HIVWorkbipolar affective disorderbipolar diseasebipolar illnessbipolar mood disordercartilage link proteinclustered regularly interspaced short palindromic repeats screencongenital infectiondefined contributiondementia praecoxdigitalhuman diseasehuman pathogenhypoimmunityimage evaluationimage interpretationimagingimmune deficiencyimmune evasiveimmunodeficiencyingestinsightintercellular communicationlink proteinmachine based learningmalignancymanic depressive disordermanic depressive illnessmembrane structuremental illnessneoplasm/cancerneurotraumanovelobligate intracellular parasiteontogenyorgan allograftorgan graftorgan xenograftprospectiveprotein complexprotein degradationpsychiatric illnesspsychological disorderrapid growthrecruitschizophrenicsecretory proteinsocial roletumor susceptibility gene 101vertebratavirtualvision lossvisual loss
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Description preview
Abstract
ESCRT protein complexes play essential roles in membrane remodeling for multivesicular body formation,
intercellular communication, formation of the nuclear envelope, and cell division. We recently showed that the
obligate intracellular parasite Toxoplasma gondii repurposes host ESCRT machinery to acquire macromolecular
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