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Defined microbial communities to prevent and eradicate infection by AMR pathogens
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Mar 2021Deadline 28 Feb 2026 β οΈ
NIHUS FederalResearch GrantFY2025AccountingAcuteAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibiotic TherapyAntibiotic TreatmentAntibioticsAntimicrobial ResistanceBackBacteriaBacterial Antibiotic ResistanceBacterial InfectionsBacteriophagesC diffC difficileC. diffC. difficileCause of DeathCessation of lifeClinical TrialsClostridioides difficileClostridium difficileColiform BacilliCommunicable DiseasesCommunitiesDeathDiagnosisDietDiseaseDisorderDorsumDrug resistanceDrugsE coliE coli InfectionsE. coliE. coli InfectionsEnteric BacteriaEnterobacteriaEnterobacteriaceaeEscherichia coliEscherichia coli InfectionsExposure toExtended-spectrum beta-lactamaseExtended-spectrum Ξ²-lactamaseFocal InfectionGI microbiomeGI microbiotaGastrointestinal microbiotaGeneralized GrowthGoalsGrowthHealth BenefitHospitalsHumanHuman FigureHuman MicrobiomeHuman bodyIn VitroIndividualInfectionInfection preventionInfectious DiseasesInfectious DisorderInflammationIntervention StrategiesIntestinalIntestinesLearningLyticMDR organismMDR pathogenMedical Care CostsMedicationMetabolicMethodsMicrobeMicrobial PhysiologyMiscellaneous AntibioticModern ManMucosaMucosal TissueMucous MembraneNutritionalOrganoidsOut-patientsOutpatientsPathogenesisPatientsPersonsPhagesPharmaceutical PreparationsPneumoniaPopulation HeterogeneityPredispositionPrevent infectionPreventative strategyPrevention strategyPreventive strategyProbioticsPropertyPublic HealthRecurrenceRecurrentResistanceResistance to antibioticsResistant to antibioticsRiskSamplingSiteSurfaceSusceptibilityTestingTherapeuticTissue GrowthTransmissionUnited StatesUrinary tract infectionUrinary tract infectious diseaseUropathogenVaginaVirulenceWorkanti-microbial resistantantibiotic drug resistanceantibiotic resistantantibiotic resistant bacteriabacteria infectionbacteria pathogenbacterial antibiotic resistantbacterial diseasebacterial disease treatmentbacterial infectious disease treatmentbacterial pathogenbacterial resistance to antibioticbacterial virusbowelcarbapenem resistancecarbapenem resistantclinical relevanceclinically relevantcolonization resistancecombatcommensal bacteriacommensal bacterial speciescommensal floracommensal microbescommensal microbiotacommensal microfloracommunity microbesdesigndesigningdietsdigestive tract microbiomediverse populationsdrug resistantdrug/agentdysbacteriosisdysbiosisdysbioticenteric microbial communityenteric microbiomeenteric microbiotaenvironmental changeexperimentexperimental researchexperimental studyexperimentsfecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal samplefecal transplantfecal transplantationgastrointestinalgastrointestinal microbial floragastrointestinal microbiomegut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehealth care associated infectionsheterogeneous populationhuman florahuman microbial communitieshuman microbiotahuman microflorahuman tissuehuman-associated microbial communitieshuman-associated microbiomehuman-associated microbiotainfection localizedinfection recurrenceinnovateinnovationinnovativeintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloralocal infectionmedical costsmedical expensesmetabolism measurementmetabolomicsmetabonomicsmicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobial imbalancemicrobiomemicrobiome communitymicrobiotamicrofloramicroorganism communitymouse modelmulti-drug resistant organismmulti-drug resistant pathogenmultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogenmultispecies consortiamurine modelnovelnutritiousontogenyopportunistic pathogenpathobiontpathogenpathogenic E colipathogenic E. colipathogenic Escherichia colipathogenic bacteriapolymicrobial communitypopulation diversitypreservationpressurepreventpreventingrecurrent infectionrecurring infectionresistance against carbapenemsresistance to Drugresistance to anti-microbialresistance to carbapenemresistantresistant to Drugresistant to antimicrobialresistant to carbapenemstool samplestool specimensuccesssynergismtissue culturetransmission processurinary infection
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Project Summary
Before the discovery of antibiotics, infectious diseases were the three leading causes of death in the United
States and constituted nearly 50% of the deaths annually. Today only one infectious disease, pneumonia, is
among the top 10 causes of death in the US, largely due to the success of antibiotics in treating bacterialβ¦
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