grant
Deconstructing the molecular and cellular mechanisms of psoriatic arthritis pain by an improved animal model
NIHUS FederalResearch GrantFY2025Active OxygenAfferent NeuronsAnabolismAnalgesia TestsAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnimal ModelAnimal Models and Related StudiesAnodynesAntinociceptive AgentsAntinociceptive DrugsArthritisAttenuatedAutoimmuneBlocking AntibodiesBloodBlood PlasmaBlood Reticuloendothelial SystemBody TissuesCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell SignalingCellsChondrocytesChronicClinicalCutaneousCutaneous DisorderCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneD-MannoseDataDermatosesDevelopmentDorsal Root GangliaGeneticGoalsHospital AdmissionHospitalizationHumanIL-17IL-17 GeneIL-17AIL-17A GeneIL-23IL17IL17 ProteinIL17 geneIL17AIL17A GeneIP injectionIndividualInflammationInflammation MediatorsInflammatoryInjectionsInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17InterleukinsInterventionIntracellular Communication and SignalingIntraperitoneal InjectionsIntrathecal InjectionsIon ChannelIonic ChannelsJAK kinaseJanus kinaseJointsKnock-outKnockoutLipidsLong-term painLysolecithinsLysophosphatidylcholinesMannanMannansMannopyranoseMannopyranosideMannoseMechanicsMediatingMediatorMedicalMembrane ChannelsMethodsMiceMice MammalsModelingModern ManMolecularMouse StrainsMovementMurineMusNociceptionNociception TestsOxygen RadicalsPainPain AssessmentPain MeasurementPain measurePainfulPathogenesisPatientsPersistent painPhenotypePhosphatidesPhospholipidsPilot ProjectsPlasmaPlasma SerumPolymersPre-Clinical ModelPreclinical ModelsPro-OxidantsProtocolProtocols documentationPsoriasisPsoriasis ArthropathicaPsoriatic ArthritisPublic HealthReactive Oxygen SpeciesRecurrent diseaseRelapsed DiseaseReportingReticuloendothelial System, Serum, PlasmaRoleSensory NeuronsSignal TransductionSignal Transduction SystemsSignalingSkinSkin DiseasesSkin Diseases and ManifestationsSolidSpinal GangliaTherapeuticTissuesTouchTouch sensationWild Type MouseWorkanimal painarthriticarthritic painarthritis painattenuateattenuatesbiological signal transductionbiosynthesisbody movementconstant paincutaneous diseasedermal diseasedermal disorderdevelopmentaldisabilitydorsal root ganglioneffectiveness validationimprovedinflammatory mediatorinsightinterleukin-23joint damagejoint degenerationjoint degradationjoint destructionjoint injuryjoint loadingjoint tissue degenerationjoint traumakeratinocytekinase inhibitorlasting painmechanicmechanicalmodel of animalmouse modelmurine modelnociceptivenovelon-going painongoing painpain assaypain behaviorpain killerpain medicationpain modelpain reliefpain relieverpainkillerpharmacologicpilot studypolymerpolymericpreventpreventingpsoriasiformpsoriaticrelieve painside effectskin disordersocial rolesuccesstactile sensationtherapeutic targettherapeutically effectivevalidate effectivenesswildtype mouse
Description preview
Modified Project Summary/Abstract Section
Psoriasis (Ps) is an autoimmune-mediated systemic inflammatory skin disease. Approximately one-third of Ps
patients eventually develop psoriatic arthritis (PsA). PsA is one of the most common forms of arthritis, impacting
around 1 million individuals in the US. Mechanical pain associated with PsA in joints…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click