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Deconstructing interactions between diet, microbiome, and immunity to gain mechanistic insight into health and disease
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Aug 2022Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY20253 HydroxybutyrateActinobacteriaActinobacteria classActinomycetesAddressAdhesionsAreaArginineAutoimmune DiseasesAutoimmune MechanismAutoimmune ProcessAutoimmune StatusAutoimmunityBacteriaBacterial GenesBacterial InfectionsBifidobacteriumCell BodyCellsCollaborationsDataDevelopmentDietDietary FactorsDiseaseDisorderDisseminated SclerosisEnvironmentEnzyme GeneEnzymesFastingGI colonizationGI microbiomeGI microbiotaGastrointestinal microbiotaGeneralized GrowthGenetic DiseasesGenetic ResearchGoalsGrowthHealthHigh G+C Gram-Positive BacteriaHumanHuman MicrobiomeImmuneImmune Cell ActivationImmune responseImmune systemImmunesImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyImmunomodulationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInstitutionIntermediary MetabolismInterventionIntestinalIntestinesKetone BodiesL-ArginineLinkMS patientMediatingMetabolic ProcessesMetabolismMiceMice MammalsMicrobeMicrobiologyMicrobiomicsMicroscopyModelingModern ManMultiple SclerosisMurineMusPatientsPositionPositioning AttributePostdocPostdoctoral FellowProductionResearchResearch AssociateRoleSeminalSeveritiesSeverity of illnessTechniquesTerpene CompoundTerpenesTerpenoidsTissue GrowthTrainingTranslational ResearchTranslational ScienceWorkalter microbiomeautoimmune conditionautoimmune disorderautoimmunity diseasebacteria in the gutbacteria infectionbacterial diseasebacterial geneticsbeta-Hydroxybutyratebowelclinical relevanceclinically relevantcolitis mouse modelcolitis murine modeldevelopmentaldietarydietary manipulationdietsdigestive tract microbiomedisease modeldisease severitydisorder modelempowermententeric microbial communityenteric microbiomeenteric microbiotafastedfastsgastrointestinal microbial floragastrointestinal microbiomegastrointestinal tract colonizationgene manipulationgenetic conditiongenetic disordergenetic manipulationgenetically manipulategenetically perturbgut bacteriagut colonizationgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehost responsehuman diseasehuman-associated microbiomeimmune activationimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinflammatory disease of the intestineinflammatory disorder of the intestineinhibitorinsightinsular sclerosisinter-individual variabilityinter-individual variationintestinal autoinflammationintestinal biomeintestinal colonizationintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraketo dietketogenic dietmembermetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial consortiamicrobial floramicrobiomemicrobiome adaptationmicrobiome alterationmicrobiome community compositionmicrobiome compositionmicrobiome perturbationmicrobiome researchmicrobiome sciencemicrobiome species compositionmicrobiome structuremicrobiome studiesmicrobiotamicrofloramicroorganismmouse colitismouse modelmultiple sclerosis patientmultispecies consortiamurine colitismurine modelnovelontogenypatients with MSpatients with multiple sclerosispeople with Multiple sclerosispost-docpost-doctoralpost-doctoral traineepreventpreventingprogramsprotective effectprotein intakeresearch associatesresearch studyskillssmall moleculesocial roletranslation researchtranslational investigationβ-Hydroxybutyrate
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Project Summary/Abstract
Intestinal immune responses are linked to the trillions of microorganisms that colonize the gastrointestinal tract.
Thus, inter-individual variations in the gut microbiome could contribute to altered immune responses that impact
immune driven diseases such as autoimmunity. Activation of T helper 17 (Th17) cells by members…
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