grant
Decoding viral transmission, tropism and inflammation: from single cell to organism
Organization NATIONAL HEART, LUNG, AND BLOOD INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAD dementiaAdultAdult HumanAlimentary CanalAllergensAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimal ModelAnimal Models and Related StudiesAntibodiesAntigen Presentation PathwayAntigen Processing and PresentationArthritisAsthmaAutoimmune StatusAutoimmunityBacterial InfectionsBiologic ModelsBiological ModelsBody TissuesBreast FeedingBreast MilkBreast fedBreastfedBreastfeedingBreastmilkBronchial AsthmaCOPDCOVID-19 infectionCOVID-19 virus infectionCOVID19 infectionCancerousCardiovascular DiseasesCell BodyCell Culture TechniquesCellsChildChild YouthChildhoodChildren (0-21)ChronicChronic DiseaseChronic IllnessChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseClinicalColonCoronaviridaeCoronavirusCot DeathCrib DeathDevelopmentDiabetes MellitusDigestive TractDiseaseDisorderDisparateDisseminated SclerosisEnzyme GeneEnzymesFoodFutureGI TractGastrointestinal TractGastrointestinal tract structureHealthHumanHuman MilkHuman Mother's MilkImmuneImmune Cell ActivationImmune systemImmunesImmunobiologyImmunophysiologyIncidenceIndividualInfantInfectionInflammationInflammatoryInflammatory ResponseInvestigationLactationLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019Lower respiratory tract structureLungLung InflammationLung Respiratory SystemMammary Gland MilkMammary glandMethodologyModel SystemModelingModern ManMother's MilkMothersMultiple SclerosisNK Cell ActivationNatural Killer Cell ActivationNeurologicNeurologicalObesityOrganismOrganoidsOrthocoronavirinaeOtitis MediaParalysis AgitansParkinsonParkinson DiseasePathway interactionsPlayPneumonitisPredispositionPrimary ParkinsonismPrimary Senile Degenerative DementiaProduce salivaPulmonary InflammationRenal functionRoleSARS-CoV-2 infectionSARS-CoV2 infectionSIDSSaliva productionSalivarySalivary GlandsSalivary excretionSalivationSamplingSevere acute respiratory syndrome coronavirus 2 infectionShapesSudden Infant DeathSudden Unexpected Infant DeathSudden infant death syndromeSusceptibilityTissuesTransmissionTropismViralViral DiseasesVirusVirus Diseasesadiposityadulthoodalimentary tractanti-microbialantimicrobialarthriticbacteria infectionbacterial diseasecardiovascular disordercell culturecell culturescell typechronic COVIDchronic COVID-19chronic disorderchronic novel coronavirus disease 2019chronic obstructive pulmonary disordercorona viruscoronavirus disease 2019 infectioncorpulencedevelopmentaldiabetesdigestive canalfightinggastrointestinal infectionhuman modelimmune activationinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2insular sclerosiskidney functionkidslactatinglactationalliving systemlong haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019lower respiratory tractmaternal milkmiddle ear infectionmodel of animalmodel of humanmouse modelmurine modelpathogenpathwaypediatricpersistent COVID-19post COVID syndromepost COVID-19 syndromepost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-acute phases of COVID-19primary degenerative dementiaprolonged COVID-19 symptomssaliva secretionsalivary productionsalivary secretionsenile dementia of the Alzheimer typesingle cell technologysocial roletissue tropismtooltransmission processviral infectionviral transmissionvirus infectionvirus transmissionvirus-induced diseaseyoungster
Description preview
Inflammation is activation of the immune system. It plays an important role for fighting infectious pathogens but unregulated contributes to the development of many childhood and adult chronic diseases including cardiovascular disease, arthritis, diabetes, Parkinsons, multiple sclerosis and Alzheimers.
Our lab studies the external and internal…
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