grant
Decoding the role of chromatin architecture in alveolar epithelial cell identity and disease
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAlveolarAlveoli progenitorAlveoli stem cellArchitectureBasal Transcription FactorBasal transcription factor genesBindingBiologic ModelsBiological ModelsCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell Growth and MaintenanceCell Growth in NumberCell LineCell MaintenanceCell MultiplicationCell ProliferationCell SignalingCellLineCellsCellular ProliferationChildhoodChromatinChromatin StructureClustered Regularly Interspaced Short Palindromic Repeats interferenceCommunicationCompetenceDataDevelopmentDiseaseDisorderEngineeringEngineering / ArchitectureEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsExposure toGasesGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenomeGenomicsGoalsHumanInjuryInterstitial Lung DiseasesIntracellular Communication and SignalingLeannessLungLung Alveolar EpitheliaLung DiseasesLung Respiratory SystemLung Tissue FibrosisLung tissue regenerationMaintenanceMapsMeasuresMediatingModel SystemModern ManModificationMolecular InteractionMorphologyNatural regenerationNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesPathologicPatientsPhenotypePlayProcessPulmonary DiseasesPulmonary DisorderPulmonary FibrosisRegenerationRegenerative responseRegulatory ElementRegulatory RegionsResearchRoleSignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesTGF-Beta 1TGF-Beta1TGFBTGFB1TGFB1 geneTechniquesTestingTherapeuticThinnessTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor Beta 1Type II CellType II Epithelial Receptor CellWorkalveolar epitheliumalveolar progenitoralveolar stem cellbiological signal transductioncell typecellular differentiationcultured cell linedetection methoddetection proceduredetection techniquedevelopmentaldisease of the lungdisorder of the lungeffective therapyeffective treatmentepigenetic regulationepigeneticallyfibrosis in the lunggene regulatory networkgenetic regulatory elementhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman tissueiPSiPSCiPSCsinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinjuriesinsightlung disorderlung fibrosislung regenerationlung repairlung tissue repairmutantoverexpressoverexpressionpediatricprogenitor cell modelprogenitor modelprogramspromoterpromotorpulmonarypulmonary regenerationpulmonary repairregenerateregeneration responserepressing CRISPR-dCas9 systemsocial rolestem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelthree dimensionaltranscription factortransdifferentiationtransforming growth factor beta1
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Project Abstract
The alveolar epithelium is composed of two distinct cell types—alveolar epithelial type I (AT1) cells, which
facilitate gas exchange, and alveolar epithelial type II (AT2) cells, which act as progenitors for AT1 cells.
Successful lung repair following alveolar injuries requires AT2 cell proliferation and differentiation into AT1…
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