grant
Decoding the role of Aire-expressing Thetis cells in peripheral self-tolerance
Organization SLOAN-KETTERING INST CAN RESEARCHLocation NEW YORK, UNITED STATESPosted 3 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AblationAddressAntigen PresentationAntigen-Presenting CellsAntigensAutoantigensAutoimmune DiseasesAutoimmune RegulatorAutoimmune StatusAutoimmunityAutologous AntigensAutoregulationBasal Transcription FactorBasal transcription factor genesBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCancersCell BodyCell DeathCellsClonal AbortionsClonal DeletionDNA mutationDataDependenceDevelopmentDiseaseDisorderEAEEctopic ExpressionEndowmentExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisGI microbiotaGastrointestinal microbiotaGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenetic ChangeGenetic ModelsGenetic TranscriptionGenetic defectGenetic mutationGenomic approachGoalsHealthHomeostasisHumanImmuneImmune ToleranceImmunesImmunologic ToleranceImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInflammationInflammatoryInformal Social ControlIntestinalIntestinesKnowledgeMalignant NeoplasmsMalignant TumorMediatingMethodsMiceMice MammalsModelingModern ManMolecularMurineMusMutationNamesOrganPathologyPathway interactionsPeripheralPhysiological HomeostasisPlayPsychological reinforcementRNA ExpressionRegulationRegulator GenesRegulatory T-LymphocyteReinforcementResearchRoleSelf RegulationSelf ToleranceSelf-AntigensSeveritiesSingle cell seqT cell differentiationT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTherapeuticThymic epithelial cellThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional Regulatory ElementsTransplantationTregWorkaccessory cellautoimmune conditionautoimmune disorderautoimmune encephalomyelitisautoimmune inflammationautoimmunity diseaseautoreactive T cellbowelcell typecentral tolerancedevelopmentaldietaryenteric microbial communityenteric microbiotafetalgastrointestinal microbial floragenetic trans acting elementgenome mutationgenomic effortgenomic strategygut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microfloraimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system toleranceimmune unresponsivenessimmunogenimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinsightintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloramalignancynamenamednamingnecrocytosisneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwayperipheral tolerancepreventpreventingprogramsregulatory T-cellsregulatory generestraintself-reactive T cellsingle cell genomicssingle cell next generation sequencingsingle cell sequencingsocial rolethymus derived lymphocytetrans acting elementtranscription factortranslational opportunitiestranslational potentialtransplant
Description preview
PROJECT SUMMARY
Establishing and maintaining immune tolerance to self-antigens is vital to prevent destructive autoimmune
inflammation. Within the thymus, Aire plays a critical role in establishing self-tolerance, acting within medullary
thymic epithelial cells (mTECs) to promote ectopic expression of tissue-restricted antigens which in turn leads…
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