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Decoding LRH-1 Activity in Gut Regeneration and Differentiation
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 14 Jun 2021Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldActive Follow-upAddressAdultAdult HumanAntigenic DeterminantsAutoimmune DiseasesAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBasic Mechanisms of SUMOylationBindingBinding DeterminantsBiologic ModelsBiological ModelsBiologyBody TissuesCPF geneCPF proteinCRISPR activationCRISPR activatorCRISPR based activationCRISPR gene activationCRISPR transcription activationCRISPR transcriptional activationCRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-dCAS9 ActivatorCRISPR-mediated transcriptional activationCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/dCas9 activationCRISPR/dCas9-based transcriptional activationCRISPRaCYP7A Promoter-Binding FactorCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell Growth in NumberCell LineageCell MultiplicationCell ProliferationCell SignalingCell SurvivalCell ViabilityCellsCellular ProliferationChromatinComplementComplement ProteinsComplexCoupledDiseaseDisorderDrug ReceptorsDrug TherapyEndocrine Gland SecretionEnteritisEnteroendocrine CellEnvironmentEpithelial CellsEpithelial PhysiologyEpitheliumEpitopesEquilibriumEvaluationExperimental DesignsFTF geneFTF proteinFundingGI Stem cellGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGoalsGut EpitheliumHB1FHealthHormonesHuman B1-Binding FactorInfectionInflammatoryInjuryIntestinalIntestinesIntracellular Communication and SignalingInvestigationKnock-outKnockoutKnowledgeLRH1Lineage TracingLiquid substanceLiver Receptor Homolog 1MapsMediatingModel SystemModelingMolecularMolecular InteractionMucosaMucosal TissueMucous MembraneNR5A2NR5A2 geneNatural regenerationNuclear Receptor Subfamily 5, Group A, Member 2Nuclear ReceptorsOrganoidsOutcomePharmacological TreatmentPharmacotherapyPhysiologyPopulationPositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProductionProgenitor CellsPropertyProtein ModificationRNA ExpressionRegenerationRegulationResearchRoleSUMOylationSecretory CellShapesSignal TransductionSignal Transduction SystemsSignalingStem Cell likeStereotypingSumoylation PathwaySupporting CellSurfaceSurvey InstrumentSurveysTechnologyTherapeuticTherapeutic HormoneTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesWorkactivating CRISPR technologyactive followupadulthoodautoimmune conditionautoimmune disorderautoimmunity diseasebalancebalance functionbasebasesbiochemical toolsbiochemistry toolsbiological signal transductionbowelcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular differentiationcellular lineage mappingcellular lineage trackingcomplementationcrypt celldesigndesigningdirected differentiationdrivingdrug developmentdrug interventiondrug treatmentepithelial progenitorepithelial progenitor cellepithelial repairepithelial stem cellfetoprotein transcription factorfluidfollow upfollow-upfollowed upfollowupgastrointestinal epitheliumgastrointestinal stem cellgut progenitorgut stem cellhealingin vivoinjuriesinjury recoveryinjury responseinjury to the intestinesinsightintestinal cryptintestinal epitheliumintestinal injuryintestinal progenitorintestinal stem cellsliquidmouse modelmurine modelmutantnoveloverexpressoverexpressionpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspluripotency factorprogenitorprogenitor capacityprogenitor cell differentiationprogenitor cell divisionprogenitor cell expansionprogenitor cell likeprogenitor cell maintenanceprogenitor cell poolprogenitor cell populationprogenitor cell renewalprogenitor cell survivalprogenitor differentiationprogenitor divisionprogenitor expansionprogenitor maintenanceprogenitor poolprogenitor populationprogenitor renewalprogenitor survivalprogenitor-likeprogramsreceptor functionrecovery after injuryrecovery following injuryrecovery post injuryregeneraterepairrepairedresponse to injuryrestorationsocial rolestemstem and progenitor cell divisionstem and progenitor cell expansionstem and progenitor cell populationstem and progenitor cell renewalstem and progenitor differentiationstem cell characteristicsstem cell depletionstem cell differentiationstem cell divisionstem cell exhaustionstem cell expansionstem cell fatiguestem cell maintenancestem cell poolstem cell populationstem cell renewalstem cell survivalstem cellsstem-likestemnesstooltranscription factor
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Project Summary/Abstract
Background:
The primary epithelial stem cell in the intestine has been known for over a decade, leading to important
observations in epithelial renewal and injury recovery. These fundamental studies have demonstrated that the
intestinal epithelium is a balanced continuum between stemness in the crypt base and…
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