grant
Deciphering the role of junctional adhesion molecule-A in neutrophil-driven inflammatory response in Alzheimer disease
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 15 Aug 2023Deadline 1 Apr 2028
NIHUS FederalResearch GrantFY20253xTg3xTg-AD mice3xTg-AD mouseAD dementiaAD modelAcuteAddressAdverse effectsAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's brainAlzheimer's disease brainAlzheimer's disease modelAlzheimers DementiaAmyloid (Aβ) plaquesAmyloid A4 Protein PrecursorAmyloid PlaquesAmyloid Protein PrecursorAmyloid beta-Protein PrecursorAmyloid β-Protein PrecursorAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAttenuatedAutoimmune DiseasesAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBCEIBehavioralBloodBlood NeutrophilBlood PlateletsBlood Polymorphonuclear NeutrophilBlood Reticuloendothelial SystemBlood SerumBlood VesselsBlood leukocyteBlood monocyteBrainBrain InflammationBrain Nervous SystemBrain VascularBreast Cancer Estrogen-Inducible SequenceCXCL1CXCL1 geneCell BodyCell RespirationCellsCellular RespirationCerebral Amyloid AngiopathyCerebral endotheliumCerebrovascular systemChronicCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalComplexCongophilic AngiopathyDNA mutationDataDegenerative Neurologic DisordersDepositDepositionDevelopmentDiseaseDisease ProgressionDisorderDisturbance in cognitionElementsEncephalitisEncephalonEndotheliumEnvironmental FactorEnvironmental Risk FactorEventExtravasationFe elementFoundationsGRO1GROAGastrointestinal Trefoil Protein PS2GenesGeneticGenetic ChangeGenetic defectGenetic mutationHemostatic AgentsHemostaticsHortega cellImmuneImmune responseImmunesImpaired cognitionInflammationInflammation MediatorsInflammatoryInflammatory ResponseInjuryInnate Immune ResponseInvadedIronKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLeakageLearningLeu-CAM Receptor FamilyLeukocyte Adhesion MoleculesLeukocyte-Adhesion Receptor FamilyLeukocyte-Adhesion ReceptorsLeukocytesLeukocytes Reticuloendothelial SystemMGSAMT-bound tauMacrophageMarrow NeutrophilMarrow leukocyteMarrow monocyteMarrow plateletMembraneMemoryMemory LossMiceMice MammalsMicrogliaMitochondriaModalityMolecularMurineMusMutationMφNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeuritic PlaquesNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurologic Degenerative ConditionsNeuron DegenerationNeutrophil ActivationNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteNull MouseOccluding JunctionsOxidative StressPSEN1PathogenesisPathologicPathologyPeptidesPeripheralPhenotypePlateletsPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPrimary Senile Degenerative DementiaProcessProteinsProteomicsRegulationRoleS182 proteinSCYB1Senile PlaquesSerumSideSpillageSynapsesSynapticSystemTFF1TFF1 geneTestingThrombocytesTight JunctionsTransgenic OrganismsTrefoil Factor 1Vascular DiseasesVascular DisorderWhite Blood CellsWhite CellZonula Occludensaerobic metabolismaerobic respirationalzheimer modelamyloid beta plaqueamyloid precursor proteinamyloid-b plaqueantagonismantagonistattenuateattenuatesautoimmune conditionautoimmune disorderautoimmunity diseaseaβ plaquesbehavior outcomebehavioral outcomeblood vessel disorderblood vessel occlusionblood vessels in the brainbrain blood vesselsbrain endothelial cellbrain endotheliumbrain microvascular endothelial cellbrain parenchymabrain vascular endothelial cellbrain vasculaturecerebral blood vesselcerebral endothelial cellcerebral microvascular endothelial cellcerebral vascularcerebral vascular endothelial cellcerebral vasculaturecerebro-vascularcerebrovascularcerebrovascular amyloidosiscerebrovascular vesselscerebrovasculaturecognitive defectscognitive dysfunctioncognitive losscored plaquecortical endotheliumcytokinedefined contributiondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentaldiffuse plaquedrivingenvironmental riskextracellulargene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome mutationgitter cellhost responsehyper-phosphorylated tauhyperphosphorylated tauimmune system responseimmunoresponseimprovedinflammatory mediatorinjuriesinjury to the vasculaturejunction adhesion moleculejunctional adhesion moleculemembrane structurememory declinemesogliamicroglial cellmicrogliocytemicrotubule bound taumicrotubule-bound taumigrationmitochondrialmonocytemouse modelmurine modelnerve cell deathnerve cell lossneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative dementianeurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuroinflammationneuroinflammatoryneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuropathologicneuropathologicalneuropathologyneutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachoxidative metabolismpS2pathogenperipheral bloodperivascular glial cellpresenilin 1 proteinpresenilin-1preventpreventingprimary degenerative dementiarecruitsenile dementia of the Alzheimer typesocial rolesynapsetangletautau Proteinstau factortranscriptomicstransgenictreatment strategyvascularvascular dysfunctionvascular injuryvasculopathywhite blood cellwhite blood corpuscleτ Proteins
Description preview
Accumulating evidence suggests that Alzheimer’s disease (AD)-related inflammation
progresses in two different but interrelated compartments: the blood and the brain,
implying that leukocytes could lead to “brain activation,” while brain inflammation may
impact the peripheral system by inflammatory mediators. AD has predominantly chronic…
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