grant
Deciphering the Molecular Genetics of VSIG10L in Barrett's Neoplasia
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 20 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAblationAccelerationActive Follow-upAddressAdenocarcinoma of the EsophagusAffectAge MonthsAssayAutoregulationBarrett EsophagusBarrett SyndromeBarrett UlcerBarrett's carcinogenesisBarrett's neoplasiaBeta Proprotein Interleukin 1BioassayBiological AssayBiological MarkersBiopsyBody TissuesC3 dC3dCancer InductionCancersCausalityCell BodyCell Communication and SignalingCell JunctionsCell SignalingCell-Cell AdhesionCellsChemopreventiveChemopreventive AgentColumnar Epithelial-Lined Lower EsophagusColumnar-Lined EsophagusComplement 3dComplement C3dComplexDNA mutationDesmosomesDevelopmentDiseaseDisorderDistalDuctDuct (organ) structureDysfunctionDysplasiaEfbn2 Gene ProductElectron MicroscopyEphrin-B2EpitheliumEplg5 Gene ProductEplg5 ProteinEsophageal AdenocarcinomaEsophageal injuryEsophageal mucous membraneEsophagusEtiologyExhibitsExposure toFamilyFunctional disorderGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenotypeGerm LinesGerm-Line MutationGlandGoalsHereditaryHereditary MutationHomeostasisHumanIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImpairmentInflammationInheritedInjuryInjury to EsophagusIntercellular JunctionsInterleukin 1betaInterleukin-1 betaInterleukin-1βIntracellular Communication and SignalingKI miceKO miceKinasesKnock-inKnock-in MouseKnock-outKnock-out MiceKnockoutKnockout MiceLERK-5 Gene ProductLERK-5 ProteinLeadLesionMacula AdherensMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMetaplasiaMetaplastic ChangeMethodsMiceMice MammalsModelingModern ManMolecularMolecular GeneticsMorphologyMucosaMucosal TissueMucous MembraneMurineMusMutant Strains MiceMutationNode of BizzozeroNull MouseOrganoidsOrthologOrthologous GeneOxidative StressPathogenesisPathologyPathway interactionsPatientsPb elementPhenotypePhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPhysiopathologyPilot ProjectsPredispositionPreinterleukin 1 BetaRecurrenceRecurrentRefluxRiskRoleSignal TransductionSignal Transduction SystemsSignalingSpot DesmosomeSquamous CellSquamous DifferentiationSquamous EpitheliumSubmucosaSusceptibilityTestingTherapeuticTissuesTransphosphorylasesUnited StatesVariantVariationWound Repairactive followupaged miceaged mouseanti-carcinogenicbio-markersbiologic markerbiological signal transductionbiomarkercancer preventioncarcinogenesiscausationchemoprevention agentcholeateclinical implementationcompare to controlcomparison controldeoxycholatedesigndesigningdevelopmentaldisease causationdyscrasiaelderly miceesophageal intestinal metaplasiaesophageal mucosaesophageal progenitorsesophageal stem cellevidence baseexome sequencingexome-seqexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupgenome mutationgenotoxicitygerm-line defectgermline varianthealingheavy metal Pbheavy metal leadhuman subjectiPSiPSCiPSCsindexinginduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinjuriesinjury and repairinterstitialknockinknockin micemalignancymicroscope imagingmicroscopic imagingmicroscopy imagingmouse modelmouse mutantmurine modelmutantneoplasm/cancernovelold micepathophysiologypathwaypilot studypreventpreventingprogramsprospectivesegregationsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssynergismthree dimensionaltranscriptome profilingtranscriptomic profilingtransdifferentiationtranslational goaltranslational missionwound healingwound recoverywound resolution
Description preview
PROJECT SUMMARY/ABSTRACT
The etiology of Barrett's esophagus (BE), a molecularly complex disorder of the distal esophagus, remains
elusive. Patients with BE are at an increased risk of developing esophageal adenocarcinoma (EAC), a lethal,
increasingly prevalent, and the most common esophageal malignancy in the U.S. Our long-term objective is to…
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