grant
Deciphering the mechanisms mediating the dichotomous effects of fever on brain function and behavior
Organization NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISMLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years oldAD/HDADHDASDAbilifyAdverse effectsAffectAgeAmphetaminesAnimal Care and Use CommitteesAnimal ModelAnimal Models and Related StudiesAnimalsAntipsychotic AgentsAntipsychotic DrugsAntipsychoticsAreaAttention deficit hyperactivity disorderAutismAutistic DisorderBehaviorBehavioralBenignBody TemperatureBrainBrain Nervous SystemBrain regionCell BodyCellsChildChild YouthChildren (0-21)ClinicalCocaineCommunicationConnector NeuronDesoxynorephedrinDevelopmentDiagnosticDiseaseDisorderDrugsEarly Infantile AutismEncephalonEnvironmental FactorEnvironmental Risk FactorEpilepsyEpileptic SeizuresEpilepticsExhibitsExposure toFASDFDA approvedFetal Alcohol ExposureFetal Alcohol Spectrum DisorderFetal ETOH ExposureFetal Ethanol ExposureFeverFrequenciesGene variantGeneticGoalsHyperactivityImmuneImmunesIn Utero Alcohol ExposureIn Utero ETOH ExposureIn Utero Ethanol ExposureInfantile AutismInfectionIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInterventionInvestigatorsKanner's SyndromeKnowledgeLearningMajor TranquilizersMajor Tranquilizing AgentsManuscriptsMediatingMedicationNerve CellsNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeuroleptic AgentsNeuroleptic DrugsNeurolepticsNeurological Development DisorderNeuronsNormal RangeNormal ValuesPharmaceutical PreparationsPhenaminePhenoprominPredispositionPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPrenatal Alcohol ExposurePrenatal ETOH ExposurePrenatal Ethanol ExposureProtocolProtocols documentationPyramidal neuronPyrexiaReportingResearchResearch PersonnelResearchersResistanceRisperidoneSeizure DisorderSeizuresSeveritiesSusceptibilitySymptomsTemperatureTherapeuticTranslatingWorkadolescent with ASDadolescent with autismadolescent with autism spectrum disorderadolescents on the autism spectrumagesalcohol-exposed pregnancyallelic variantalleviate symptomameliorating symptomaripiprazoleautism attributesautism indicatorautism spectral disorderautism spectrum disorderautism spectrum disorder featuresautism spectrum disorder indicatorautism spectrum disorder symptomsautism symptomologyautism symptomsautism-like symptomsautism-related attributesautistic adolescentautistic childrenautistic featuresautistic individualsautistic peopleautistic spectrum disorderautistic symptomsautistic traitsautistic youthautistic-like symptomschildren on the autism spectrumchildren with ASDchildren with autismchildren with autism spectrum disorderdecrease symptomdevelopmentaldl-Amphetaminedrug/agenteffective therapyeffective treatmentenvironmental riskepilepsiaepileptic encephalopathiesepileptogenicexposed to alcohol prenatallyfebrilefebrisfewer symptomsgenetic variantgenomic variantgestation ETOH exposuregestation alcohol exposuregestation ethanol exposuregestational ethanol exposurehippocampal pyramidal neuronhuman subjecthuman tissueimprovedin uteroindividuals on the autism spectrumindividuals on the spectrumindividuals with ASDindividuals with autismindividuals with autism spectrum disorderinnovateinnovationinnovativeinterestkidsmodel of animalneural circuitneural circuitryneural networkneurocircuitryneurodevelopmental diseaseneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpeople on the autism spectrumpeople with ASDpeople with autismpeople with autism spectrum disorderpregnancy ETOH exposurepregnancy alcohol exposurepregnancy ethanol exposureprenatally alcohol exposedprenatally exposed to alcoholreduce symptomsrelieves symptomsrepetitive behaviorresistantresperidonesymptom alleviationsymptom reductionsymptom reliefsynaptic circuitsynaptic circuitrytherapeutic targettreatment strategyvoltage gated channelyoungsteryouth on the autism spectrumyouth with ASDyouth with autismyouth with autism spectrum disorder
Description preview
The renewal of the animal protocol “Deciphering the mechanisms mediating the dichotomous effects of fever on brain function and behavior” was approved by the Animal Care and Use Committee on 07/29/2023. Despite the challenges posed by the loss of key research personnel in early 2025, we have made significant progress across several areas of study.…
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