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Deciphering molecular mechanisms of Epithelial Plasticity
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Dec 2021Deadline 31 May 2025 ⚠️
NIHUS FederalResearch GrantFY2025AKTAKT3AKT3 geneAXL ProteinAkt proteinAssayAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBody TissuesBreast CancerC-K-RASCancer BiologyCancer CauseCancer EtiologyCancer GenesCancer TreatmentCancer-Promoting GeneCancersCarcinoma CellCell BodyCell LineCell LocomotionCell MigrationCell MovementCell SurvivalCell ViabilityCellLineCellsCellular MigrationCellular MotilityCessation of lifeChemoresistanceChronicDKFZP434N0250DNA Damage RepairDNA RepairDNA mutationDataDeathDevelopmentDisseminated Malignant NeoplasmDistantDrugsEpitheliumExhibitsFibroblastsGene AmplificationGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGlial Cell TumorsGlial NeoplasmGlial TumorGliomaGoalsHumanImmune PrecipitationImmunofluorescenceImmunofluorescence ImmunologicImmunoprecipitationInvadedIsoformsK-RAS2AK-RAS2BK-RasK-Ras 2AK-Ras-2 OncogeneKRASKRAS2KRAS2 geneKi-RASLineage TracingLocationMalignant Breast NeoplasmMalignant CellMalignant Epithelial CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMediatingMedicationMesenchymalMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic TumorModern ManMolecularMolecular InteractionMutationNF-KB-Activating KinaseNF-KB-Activating Kinase NAKNeoplasm MetastasisNeuroglial NeoplasmNeuroglial TumorOncogene K-RasOncogenesOncogenesisOrganOrganoidsPDAC cancer cellPDAC cellPKBGPRKBGPTK ReceptorsPancreas CancerPancreas Ductal AdenocarcinomaPancreatic CancerPancreatic Ductal AdenocarcinomaParacrine CommunicationParacrine SignalingPathway interactionsPatientsPatternPharmaceutical PreparationsPhenotypePostdocPostdoctoral FellowProcessPrognosisProtein IsoformsProtein Kinase BProteinsProto-Oncogene Proteins c-aktPublishingRAC-GAMMARAC-PK proteinRASK2RNA ExpressionReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneRelapseResearchResearch AssociateResistanceRoleSecondary NeoplasmSecondary TumorSingle cell seqStrains Cell LinesTANK Binding Kinase TBK1TANK-binding kinase 1TechniquesTechnologyTherapeuticTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransforming GenesTransmembrane Receptor Protein Tyrosine KinaseTumor CellTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsTyrosine-Protein Kinase Receptor UFOUFO oncogene proteinUnscheduled DNA SynthesisWorkanti-cancer therapyaxl receptor tyrosine kinasec-akt proteincancer cellcancer metastasiscancer microenvironmentcancer progressioncancer therapycancer typecancer-directed therapycell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell motilitycellular lineage mappingcellular lineage trackingchemoresistantchemotherapy resistancechemotherapy resistantcombatcultured cell linedevelopmentaldrivingdrug/agenteffective therapyeffective treatmentepithelial to mesenchymal transitionexperimentexperimental researchexperimental studyexperimentsgain of functiongenome mutationglial-derived tumorin vivoloss of functionmalignancymalignant breast tumormigrationmutantnatural gene amplificationneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionneuroglia neoplasmneuroglia tumornew approachesnovelnovel approachesnovel strategiesnovel strategypancreatic cancer cellspancreatic ductal adenocarcinoma cellpancreatic malignancypancreatic tumor cellspathwaypharmacologicpost-docpost-doctoralpost-doctoral traineeprogramsprotein expressionproto-oncogene protein RACproto-oncogene protein aktrac protein kinaserelated to A and C-proteinresearch associatesresistantresponsesingle cell next generation sequencingsingle cell sequencingslugsocial roletranscription factortumortumor cell metastasistumor microenvironmenttumor progressiontumorigenesisufo receptorv-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog
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Project Summary/Abstract
Cellular plasticity, a feature associated with epithelial-to-mesenchymal transition (EMT), contributes
to tumor cell survival, migration, invasion, and therapy resistance. Across human cancer, tumors that are high
grade, poorly differentiated, and have undergone EMT carry a worse prognosis with a high likelihood of…
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