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Deciphering molecular mechanisms of Epithelial Plasticity

Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Dec 2024Deadline 31 May 2025 ⚠️
NIHUS FederalResearch GrantFY2025Body TissuesBreast CancerCancer BiologyCancer CauseCancer EtiologyCancer GenesCancer TreatmentCancer-Promoting GeneCancersCell BodyCell SurvivalCell ViabilityCellsCessation of lifeChronicCuesDNA mutationDeathDevelopmentDisseminated Malignant NeoplasmDistantEpitheliumExhibitsGenetic ChangeGenetic defectGenetic mutationHumanImageImmune systemInvadedLineage TracingMalignant Breast NeoplasmMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic Renal Cell CancerMetastatic Renal Cell CarcinomaMetastatic TumorModelingModern ManMolecularMutationNeoplasm MetastasisOncogenesOrganOrganoidsParacrine CommunicationParacrine SignalingPatientsPhenotypePostdocPostdoctoral FellowProcessPrognosisRelapseResearchResearch AssociateResistanceRoleSecondary NeoplasmSecondary TumorSystemTechnologyTissuesTransforming GenesTumor Cellanti-cancer therapycancer cellcancer metastasiscancer microenvironmentcancer progressioncancer therapycancer-directed therapycell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingdevelopmentalepithelial to mesenchymal transitionextracellulargenome mutationimagingin vivolive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignancymalignant breast tumormigrationneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnovelpost-docpost-doctoralpost-doctoral traineeprogramsresearch associatesresistantsingle cell analysissocial roletumortumor cell metastasistumor microenvironmenttumor progression

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Project Summary/Abstract
Cellular plasticity, a feature associated with epithelial-to-mesenchymal transition (EMT), contributes to
tumor cell survival, migration, invasion, and therapy resistance. Across human cancer, tumors that are high
grade, poorly differentiated, and have undergone EMT carry a worse prognosis with a high likelihood of…

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Deciphering molecular mechanisms of Epithelial Plasticity — VANDERBILT UNIVERSITY MEDICAL CENTER | UNITED STATES | Dec 2 | Dev Procure