grant
Deciphering Mechanosignaling Using Multi-fluorescence Biomembrane Force Probe
Organization UNIVERSITY OF TEXAS MED BR GALVESTONLocation GALVESTON, UNITED STATESPosted 1 Sept 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025Basic ResearchBasic ScienceBiomechanicsBody TissuesCell BodyCell Communication and SignalingCell SignalingCellsCommunicationDiagnosticDiseaseDisorderFamilyFluorescenceFutureGenetics-MutagenesisGrantHomeIn VitroIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingLifeLigand BindingMechanoreceptor CellMediatingMentorshipMethodologyMethodsMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMolecular StereochemistryMutagenesisMutagenesis Molecular BiologyPathogenesisPathologyPhysiologyPlayPrincipal InvestigatorReceptor ProteinResearchRoleScientistSecureSeminalSignal TransductionSignal Transduction SystemsSignalingSpectroscopySpectrum AnalysesSpectrum AnalysisStructureStudy modelsSystemTechnologyTherapeuticTissuesTrainingTranslatingTranslational ResearchTranslational ScienceTransmissionWorkbiological signal transductionbiomechanicalbiophysical modelcell engineeringcellular engineeringconformationconformationalconformational stateconformationallyconformationsdisease diagnosisexperiencehomesimprovedin silicoinsightmolecular dynamicsmolecular modelingnew approachesnovel approachesnovel strategiesnovel strategyprogramsreceptorsocial rolesuccesssuperresolution imagingtranslation researchtranslational investigationtransmission process
Description preview
Project Summary/Abstract
This R35 proposal represents a comprehensive program that dives into the understanding of mechanosignaling,
while providing training and mentorship to young scientists. The principal investigator (PI) has over a decade of
experience in molecular and cellular mechanobiology in the context of both basic science and…
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