grant
Deciphering impact of immunoreceptor tyrosine-based activation motifs in natural killer cells
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 20 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026ARAMActivated Natural Killer CellAg Recognition Activation MotifAmino AcidsAntibodiesAutomobile DrivingBindingBiologyCD16CD16BCD3CD3 AntigensCD3 ComplexCD3 moleculeCMV infectionCalibrationCancer ModelCancerModelCancerousCancersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell ProtectionCell SignalingCell Surface ReceptorsCell TherapyCellsCellular FunctionCellular PhysiologyCellular ProcessClinicCoinComplexCytomegalic Inclusion DiseaseCytomegalovirus InfectionsCytoplasmic DomainCytoplasmic TailCytoprotectionCytotoxic cellDAP12DevelopmentDiseaseDisorderDysfunctionEarly DiagnosisEnvironmentExhibitsFCGR3BFCGR3B geneFaceFc Receptor III-1Fc gamma IIIb receptorFc-Gamma RIII-BetaFc-Gamma RIIIBFcRIIIBFunctional disorderHerpesvirus 1 (beta), MuridITAMIgG Fc Receptor IIIBImmuneImmune Cell ActivationImmune mediated therapyImmune systemImmunesImmunologically Directed TherapyImmunoreceptor Tyr-Based Activation MotifImmunoreceptor Tyrosine-Based Activation MotifImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyIn VitroInclusion DiseaseIntracellular Communication and SignalingK lymphocyteKARAPLength of LifeLigandsLongevityLow Affinity IgG Fc Receptor IIIBLow Affinity Immunoglobulin Gamma Fc Region Receptor III-BLymphocyte FunctionMalignant NeoplasmsMalignant TumorMeasuresMediatingMembraneMiceMice MammalsModelingMolecular InteractionMouse CytomegalovirusMurid herpesvirus 1MurineMurine CytomegalovirusMusMyeloid CellsNK Cell ActivationNK CellsNatural Killer Cell ActivationNatural Killer CellsOKT3 antigenPLO-SLPLOSLPhenotypePhosphorylationPhysiopathologyPlaque AssayPlayProtein PhosphorylationReagentReceptor ProteinReportingResistanceRoleSalivary Gland Virus DiseaseSentinelSignal TransductionSignal Transduction SystemsSignalingStudy modelsSubcellular ProcessSurfaceT-CellsT-LymphocyteT3 AntigensT3 ComplexT3 moleculeTYROBPTYROBP geneTechnologyTherapeuticTyrosineViralViral DiseasesVirus Diseasesaminoacidbiological signal transductioncancer microenvironmentcell based interventioncell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular therapeuticcellular therapycrosslinkcytoprotectivedevelopmentaldisableddrivingearly detectionfacesfacialfitnessimmune activationimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivo Modelinsightmalignancymembermembrane structuremouse modelmurine modelmutantneoplasm/cancerpathogenpathophysiologyreceptorreceptor expressionresistantresponsesocial rolethymus derived lymphocytetumortumor microenvironmentviral infectionvirus infectionvirus-induced disease
Description preview
PROJECT SUMMARY
Natural killer (NK) cells are critical members of the immune system tasked with recognizing and eliminating
harmful cells, including virally infected and cancerous cells. They recognize harmful cells (target cells) through
membrane bound NK receptors (NKR) that interact with ligands on the surface of targets. Upon cross-linking of…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click