grant
Deciphering Genetic Susceptibility of Pemphigus through Immunomics
Organization UNIVERSITY OF NORTH CAROLINA CHARLOTTELocation CHARLOTTE, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAffectAllelesAllelomorphsAntibodiesAntibody ResponseAntigensAreaArthropod VectorsAssayAutoantibodiesAutoantigensAutoimmuneAutoimmune DiseasesAutoimmune StatusAutoimmunityAutologous AntigensBacteriophagesBioassayBiologicalBiological AssayBlebBlisterBlood SerumBullaBullous LesionCausalityCell BodyCellsCellular Immune FunctionClass I AntigensClass I Major Histocompatibility AntigensComplexComplex Class 1Cutaneous DisorderDataDermatosesDiseaseDisease MarkerDisorderEnvironmental FactorEnvironmental Risk FactorEtiologyGWA studyGWASGene ExpressionGene variantGenesGenetic DiversityGenetic PolymorphismGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic VariationGenetic propensityGenomicsGeographic AreaGeographic LocationsGeographic RegionGeographical LocationGoalsHL-A AntigensHLA AntigensHealthHigh PrevalenceHistocompatibility Antigens Class IHistocompatibility ComplexHistocompatibility ComplicesHumanHuman GenomeHuman Leukocyte AntigensImmune responseImmune systemIndividualInherited PredispositionInherited SusceptibilityInsect BitesIntercistronic RegionIntergenic RegionsInvestigationKnowledgeLeukocyte AntigensLifeMHC Class I MoleculeMHC Class I ProteinMHC class I antigenMajor Histocompatibility ComplexMajor Histocompatibility Complex Class 1Major Histocompatibility ComplicesMapsMeasuresMedicalModern ManPBMCPathogenesisPatientsPemphigusPemphigus VulgarisPeripheral Blood Mononuclear CellPhage DisplayPhagesPlayPopulationPredispositionPrevalencePreventionPreventiveProcessQTLQuantitative Trait LociRNA SeqRNA sequencingRNAseqRegulationResolutionRiskRoleSamplingSelf-AntigensSerumSkin DiseasesSkin Diseases and ManifestationsSusceptibilityT-CellsT-LymphocyteTechnologyTranscriptUnderrepresented GroupsUnderrepresented PopulationsUnited StatesValidationVariantVariationVesicationViralViral AntigensVirusadulthoodallelic variantautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodybacterial virusbiologiccausal allelecausal genecausal mutationcausal variantcausationcausative mutationcausative variantcohortcutaneous diseasedermal diseasedermal disorderdesmogleindisease causationdisease preventiondisorder preventiondisparity in healthenvironmental riskexperiencegenetic associationgenetic etiologygenetic informationgenetic mechanism of diseasegenetic variantgenetic vulnerabilitygenetically predisposedgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic variantgeographic sitehealth disparityhigh riskhost responsehuman diseasehuman whole genomeimmune functionimmune system responseimmunogenimmunoresponseinsightinterestlong read seqlong-read sequencinglong-read transcript sequencingmultiomicsmultiple omicsneglectnovelpanomicspatient profilepolymorphismprofiles in patientsresolutionsscRNA sequencingscRNA-seqscreeningscreeningsself reactive antibodysingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskin disordersocial roletherapeutic targetthymus derived lymphocytetooltranscriptome sequencingtranscriptomic sequencingtranscriptomicsunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peoplevalidationsviral microbiomeviromevirus antigenwhole genome association analysiswhole genome association study
Description preview
ABSTRACT
Pemphigus is a broad term denoting a subset of potentially life-threatening autoimmune blistering skin diseases
with a prevalence of 5.2 cases per 100,000 adults in the United States. Pemphigus foliaceus (PF) is a unique
disease intimately related to environmental factors that trigger the disease in genetically susceptible individuals…
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