grant
Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
Organization CHILDREN'S HOSPITAL OF LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 20 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldARDSARDS in childrenAccountingAcute Respiratory DistressAcute Respiratory Distress SyndromeAddressAdultAdult ARDSAdult HumanAdult RDSAdult Respiratory Distress SyndromeAgeAlveolarAlveolusAng-2Ang2Angiopoietin-2Anti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAnticoagulationAreaBiologicalBiological MarkersBlood PlasmaBlood gasBronchial AlveolusCapnographiesCapnographyChildChild YouthChildhoodChildren (0-21)Clinical MarkersClinical TrialsClinical Trials DesignDa Nang LungDataDrug TherapyDrugsEnrollmentExtracorporeal Membrane OxygenationFutureGasesHeterogeneityHypoxemiaIndividual DifferencesInflammatoryInterventionInvestigatorsKidney FailureKidney InsufficiencyLengthLow Cardiac OutputLungLung Respiratory SystemLung damageMeasuresMedicationMeta-AnalysisMethodsMicrovascular DysfunctionModelingMorbidityMorbidity - disease rateNHLBINational Heart, Lung, and Blood InstituteObservation researchObservation studyObservational StudyObservational researchOrgan failurePAI-1PAI1PLANH1Patient MonitoringPatient SelectionPatientsPediatric ARDSPediatric Acute Lung InjuryPediatric Acute Respiratory DistressPediatric Acute Respiratory Distress SyndromePerfusionPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhenotypePlasmaPlasma SerumPlasminogen Activator Inhibitor 1ProductionReceptor ProteinRefractoryRenal FailureRenal InsufficiencyResearchResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRiskRisk MarkerRistocetin CofactorRistocetin-Willebrand FactorSepsisSerine or Cysteine Proteinase Inhibitor Clade E Member 1SeveritiesSeverity of illnessShock LungShuntShunt DeviceSiteStiff lungSubgroupSurvivorsTestingThrombomodulinTidal VolumeTimeType 1 Plasminogen Activator InhibitorVasodilating AgentVasodilator AgentsVasodilator DrugsVasodilatorsVentilatoradulthoodagesbio-markersbiologicbiologic markerbiological heterogeneitybiomarkerclinical biomarkersclinical relevanceclinically relevantclinically useful biomarkersco-morbidco-morbiditycohortcomorbiditycostdeath riskdisease severitydrug interventiondrug treatmentdrug/agenteffective therapyeffective treatmentenrollexperienceglycationhigh riskhypoxemiciNOimprovedindexinginhaled nitric oxidekidslung functionlung injurymicrovascular complicationsmicrovascular diseasemortalitymortality risknon-enzymatic glycosylationnonenzymatic glycosylationobservational cohort studyoff-label applicationoff-label prescribingoff-label usepediatricpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprognosticprospectivepulmonarypulmonary damagepulmonary functionpulmonary injurypulmonary tissue damagepulmonary tissue injuryreceptorrespiratory airway volumeresponseresponse to therapyresponse to treatmentrisk predictorrisk predictorsrisk stratificationsecondary outcomeshuntssmall vessel diseasestratify risktherapeutic responsetherapy responsetreatment effecttreatment responsetreatment responsivenessventilationvon Willebrand Factorvon Willebrand Proteinwet lungyoungster
Description preview
PROJECT SUMMARY
Mortality remains high (20%) for the 8,000 US children each year that develop pediatric acute respiratory
distress syndrome (ARDS). No pharmacologic therapies have been identified that decrease the mortality risk
from ARDS. This is likely due to underlying biologic heterogeneity among patients with ARDS that may result in
some…
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