grant

De novo Design of Proteins for Catalysis and Fluorescence Imaging

Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20261,2-Benzopyrones1,2-benzopyroneAchievementAchievement AttainmentAffinityAutomobile DrivingBenchmarkingBest Practice AnalysisBindingBinding ProteinsBiologicalBiological FunctionBiological ProcessBiomedical EngineeringCatalysisCell Communication and SignalingCell SignalingCoumarinsCovalent InteractionCrystallographiesCrystallographyDevelopmentEngineeringEnzyme GeneEnzymesEvolutionExhibitsFoundationsFutureGenetics-MutagenesisIntracellular Communication and SignalingIsomeraseIsomerase GeneKineticsKnowledgeLabelLigand BindingLigand Binding ProteinLigand Binding Protein GeneLigandsMethodsModernizationModificationMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryMutagenesisMutagenesis Molecular BiologyNaturePhosphatesPlayPositionPositioning AttributeProductivityPropertyProtein BindingProtein DynamicsProtein EngineeringProteinsReactionReportingRhodamineRoleSignal TransductionSignal Transduction SystemsSignalingSingle Crystal DiffractionSiteStructureTestingTonka Bean CamphorTrainingWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyalpha benzopyroneapplication in practicebasebasesbenchmarkbio-engineeredbio-engineersbioengineeringbiologicbiological engineeringbiological signal transductionbiological systemsbound proteinconformationconformationalconformational stateconformationallyconformationscovalent bonddesigndesigningdevelopmentaldrivingexperiencefluorescence imagingfluorescent imagingfluorophorefrontiergenetic protein engineeringinorganic phosphateinsightinterdisciplinary approachmolecular dynamicsmolecular recognitionmultidisciplinary approachmutantnovelpractical applicationprotein designprotein functionscreeningscreeningssmall moleculesocial rolesuccesstooltraining opportunity
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Project Summary/Abstract
Protein-small molecule interactions regulate protein function, signal transduction, and enzymatic catalysis in

biological systems. Advances in protein engineering have enabled modifications of natural protein-small

molecule interactions for diverse applications, including developing protein tags for fluorescence imaging…

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De novo Design of Proteins for Catalysis and Fluorescence Imaging — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | UNITED STA | Dev Procure