grant

DCEG- Genotyping for epidemiology studies

Organization LEIDOS BIOMEDICAL RESEARCH, INC.Location FREDERICK, UNITED STATESPosted 31 Aug 2025Deadline 30 Aug 2026
NIHUS FederalResearch GrantFY2025Active Follow-upAffectAmerican Cancer SocietyAreaAssayBasic ResearchBasic ScienceBioassayBiological AssayBody TissuesCancer BurdenCancersCervical Cancer ScreeningColonCustomDCEGDNADNA mutationDataData AnalysesData AnalysisData Storage and RetrievalDeoxyribonucleic AcidDevelopmentDiseaseDisease OutcomeDisorderDivision of Cancer Epidemiology and GeneticsElectronicsEmploymentEnvironmental FactorEnvironmental Risk FactorEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiologistEpidemiology ResearchExperimental DesignsFamilyGWA studyGWASGene variantGenerationsGenesGeneticGenetic ChangeGenetic DiversityGenetic MarkersGenetic VariationGenetic defectGenetic mutationGenome ScanGenomicsGenotypeHPVHeritabilityHuman GenomeHuman Papilloma VirusHuman PapillomavirusImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIndividualInfectious Human Wart VirusInformaticsInformation ManagementIntramural ProgramIntramural Research ProgramLaboratoriesLaboratory ResearchLungLung Respiratory SystemMalignant NeoplasmsMalignant TumorMeta-AnalysisMolecular EpidemiologyMutationNational Cancer BurdenNormal TissueNormal tissue morphologyNucleic AcidsOutcomeOvarianPhenotypePopulationPopulation GroupPredispositionProstateProstate GlandProstatic GlandPublishingResearchResearch ResourcesResearch SpecimenResearch SupportResourcesSamplingScanningScientistSelf-Help GroupsSolateneSpecimenStatistical MethodsSupport GroupsSurvey InstrumentSurveysSusceptibilityTechniquesTechnologyTissuesWorkactive followupallelic variantanti-cancer researchbeta,beta-Carotenebio-informatics pipelinebioinformatics pipelinecancer genomicscancer preventioncancer researchcervical cancer early detectioncervical screeningclinical relevanceclinically relevantcohortcostcustomsdata accessdata interpretationdata retrievaldata storagedatabase of Genotypes and PhenotypesdbGaPdesigndesigningdevelopmentaldigitaldigital pathologyelectronicelectronic deviceenvironmental riskepidemiologic investigationepidemiology studyexomeexome sequencingexome-seqfollow upfollow-upfollowed upfollowupgene biomarkergene expression biomarkergene markergene signature biomarkergenetic biomarkergenetic epidemiologic studygenetic epidemiologygenetic variantgenome mutationgenome scalegenome sequencinggenome wide associationgenome wide association scangenome wide association studygenome-widegenome-wide scangenomewidegenomewide association scangenomewide association studygenomewide scangenomic varianthuman genomicshuman whole genomeimaginginterestlow-frequency mutationmalignancymolecular pathologyneoplasm/cancernoveloncogenomicsprecancer cervical detectionrare allelerare mutationrare variantresponsescreeningscreeningsself help organizationstatistic methodstissue processingtumorwart viruswhole genome association analysiswhole genome association studywhole-genome scanα-Tocopherolβ-Carotene
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Full Description

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians, and basic research scientists in DCEG’s intramural research program, the CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. New work has begun in somatic research with the use of tumor/normal tissue nucleic acids for cross-platform comparisons in subjects of interest. A support group for molecular and digital pathology research within CGR has been added to support these efforts.

CGR supports DCEG in all stages of cancer research from planning to publishing, including experimental design and project management, sample handling, genotyping and sequencing assay design and execution, tissue research support, development and implementation of bioinformatic pipelines, and downstream research and analytical support. These factors make CGR a unique collaborative center for NCI-driven scientific endeavors.

Grant Number: 75N91019D00024-0-759102500016-18
NIH Institute/Center: NIH
Principal Investigator: lynn briscoe

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