grant
Data-driven discovery of host-microbiome protein-protein interactions
NIHUS FederalResearch GrantFY2025AccelerationAddressAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAssayBacterial Gene ProductsBacterial Gene ProteinsBacterial ProteinsBacteroidesBindingBinding ProteinsBioassayBiological AssayBiotinylationCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCell BodyCell JunctionsCellsColitisD-Glucose-6-phosphate phosphohydrolaseDataData BasesDatabasesDevelopmentDiabetes MellitusDiagnosticDiseaseDisorderDrug TargetingDrugsDysfunctionFoodFunctional MetagenomicsFunctional disorderGI microbiomeGenesGlucose-6-Phosphate PhosphohydrolaseGoalsHealthHigh Throughput AssayHumanHuman MicrobiomeImmuneImmunesIn SituIndividualInflammationIntegraseIntercellular JunctionsLabelLanguageLigand Binding ProteinLigand Binding Protein GeneLigandsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetagenomicsMethodsMiceMice MammalsMicrobeMicrobiomicsModelingModern ManMolecularMolecular InteractionMurineMusNaturePathogenicityPathway interactionsPatternPharmaceutical PreparationsPhysiologyPhysiopathologyProductionProtein BindingProteinsReceptor ProteinReporterResearchRoleScanningSignal PathwaySiteSourceStructureSurface ProteinsTIL4TLR2TLR2 geneTLR2 receptorTestingTherapeuticToll-Like Receptor 2Toll/Interleukin 1 Receptor-Like 4Toll/Interleukin 1 Receptor-Like 4 GeneToll/Interleukin 1 Receptor-Like Protein 4UbiquitilationUbiquitinationUbiquitinoylationValidationWorkbound proteincase controlcase-controlledcase-controlled studiescohortcommensal communitycommensal microbiomecommensal speciescomputer based predictioncostdata basedeep learning based modeldeep learning modeldevelopmentaldiabetesdigestive tract microbiomedrug/agententeric microbiomeevidence baseexperimentexperimental researchexperimental studyexperimentsgastrointestinal microbiomeglucose-6-phosphatasegut microbiomegut-associated microbiomehigh throughput screeninghost microbiomehuman diseasehuman-associated microbiomeimprovedinsightintestinal barrierintestinal biomeintestinal microbiomeintestinal mucosal barrierisletlenslensesmembrane structuremicrobe pathogenmicrobialmicrobial pathogenmicrobiomemicrobiome researchmicrobiome sciencemicrobiome studiesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon-synonymous mutationnonsynonymous mutationnonsynonymous single nucleotide polymorphismnonsynonymous single nucleotide variantnonsynonymous single-nucleotide substitutionnonsynonymous variantnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenic microbepathophysiologypathwaypredictive modelingpredictive toolsprotein functionprotein protein interactionreceptorresident commensalsscreeningscreeningssmall moleculesocial roleubiquinationubiquitin conjugationvalidations
Description preview
Research Summary
Despite numerous large-scale metagenomic case-control studies that associate microbial taxa and
genes with specific diseases, surprisingly little is known about the molecular mechanisms underlying these
associations. Much of the mechanistic microbiome research to date cites the production of small molecules,
immune interactions…
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