grant

Cytoskeletal force-sensing mechanisms

Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 Apr 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026Actin FilamentsActin-Activated ATPaseActin-Binding ProteinActinsAdhesion MoleculeAutoregulationBiochemicalBiological FunctionBiological ProcessBiophysicsBody TissuesCancersCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell-Extracellular MatrixCellsCellular FunctionCellular MatrixCellular MechanotransductionCellular PhysiologyCellular ProcessCellular biologyChemicalsComputer AnalysisCrosslinkerCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyCytoskeletal GeneCytoskeletal ProteinsCytoskeletal SystemCytoskeletonDevelopmentDiseaseDisorderDissectionDysfunctionECMElectron CryomicroscopyEnvironmentExtracellular MatrixF-ActinF-actin-binding proteinsFibrosisFilamentous ActinFunctional disorderGene ExpressionGenerationsGenesGeometryHomeostasisHumanIn VitroIndividualIntracellular Communication and SignalingLINLobular Intraepithelial NeoplasiaLobular NeoplasiaMachine LearningMalignant NeoplasmsMalignant TumorMechanical Signal TransductionMechanicsMechanosensory TransductionMediatingMicrofilamentsModern ManMolecularMolecular MotorsMotorMuscular DystrophiesMyodystrophicaMyodystrophyMyofilamentsMyosin ATPaseMyosin Adenosine TriphosphataseMyosin AdenosinetriphosphataseMyosinsNuclearPathway interactionsPhysiological HomeostasisPhysiologyPhysiopathologyPreparationProcessProteinsResearchSamplingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStructureSubcellular ProcessTherapeuticTissuesTranscriptional ControlTranscriptional RegulationTransducersTransmissionVisualizationWorkZYXZYX genebiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescell adhesion proteincell biologycomputational analysescomputational analysiscomputer analysescryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydevelopmentalelectron cryo-tomographyfluid flowin vivoinnovateinnovationinnovativeinsightintracellular skeletonmachine based learningmalignancymechanicmechanicalmechanical cuemechanical signalmechanosensingmechanotransductionmuscle dystrophyneoplasm/cancerpathophysiologypathwaypreparationsprotein crosslinkprotein protein interactionprotein structureprotein structuresproteins structurereconstitutereconstitutionrepairrepairedtransmission processzyxin
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Description preview

Cells perceive mechanical cues in their local environments, which must be converted into intracellular
biochemical signals to modulate cellular physiology and control gene expression. This process of mechanical

signal transduction (“mechanotransduction”) is critical for development and frequently dysfunctions in disease

states such as cancer.…

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Cytoskeletal force-sensing mechanisms — ROCKEFELLER UNIVERSITY | UNITED STATES | Apr 2026 | Dev Procure