grant
Cytoskeletal compartmentalization of apoptotic signaling
Organization UNIVERSITY OF CONNECTICUT STORRSLocation STORRS-MANSFIELD, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025APAF1 ProteinAPI3Actin FilamentsActin-Binding ProteinActinsAddressAffectAntioncogene Protein p53Apaf-1Apaf-1 proteinApaf-1L proteinApopainApoptosisApoptosis PathwayApoptosis-Related Cysteine Protease Caspase 3ApoptoticApoptotic Protease Activating FactorBIRC4BIRC4 geneBindingBiochemicalBiogenesisBiologicalBiophysicsBundlingCASP-3CASP3CASP3 geneCPP-32CPP32CPP32 proteinCPP32BCPP32betaCaspaseCaspase GeneCaspase InhibitorCell BodyCell Communication and SignalingCell DeathCell FunctionCell Membrane PermeabilityCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell-Death ProteaseCellsCellular FunctionCellular MatrixCellular PhysiologyCellular ProcessCellular Tumor Antigen P53Cellular biologyCommunicationComplexCouplingCysteine EndopeptidasesCysteine ProteaseCysteine Protease CPP32Cysteine Protease CPP32 GeneCysteine ProteinasesCytochrome aCytoskeletal SystemCytoskeletonDNA DamageDNA InjuryDataDiffuseDiseaseDisorderEnsureF-ActinFamily memberFerricytochrome cFerrocytochrome cFilamentous ActinG ActinGeneticGlobular ActinGoalsHumanICE-like proteaseIn VitroIndividualInterdisciplinary ResearchInterdisciplinary StudyInterphase CellIntracellular Communication and SignalingLinkMeasuresMediatingMediatorMicrofilamentsMicroscopyMitochondriaModelingModern ManMolecularMolecular InteractionMultidisciplinary CollaborationMultidisciplinary ResearchMutateMyofilamentsNon-dividing CellNondividing CellOncoprotein p53Origin of LifeOuter Mitochondrial MembraneP53PARP Cleavage ProteasePARP Cleavage Protease GenePaperParticipantPathway interactionsPatternPhosphoprotein P53Phosphoprotein pp53PolymersProcessProgrammed Cell DeathProtein BiochemistryProtein CleavageProtein FamilyProtein TP53Protein/Amino Acid BiochemistryProteinsProteolysisR-Series Research ProjectsR01 MechanismR01 ProgramResearch GrantsResearch Project GrantsResearch ProjectsResistanceResting CellRoleSCA-1SCA-1 GeneSREBP Cleavage Activity 1SREBP Cleavage Activity 1 GeneSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSkeletonStressStructureSubcellular ProcessTP53TP53 geneTRP53TestingTextbooksTumor Protein p53Tumor Protein p53 GeneWiskott-Aldrich syndrome proteinXIAPYamaYama proteinapoptotic protease-activating factor 1basebasesbiologicbiological signal transductionbiophysical analysisbiophysical foundationbiophysical principlesbiophysical sciencesbiophysical studiescaspase-3cell biologycrosslinkcystein proteasecystein proteinasecysteine endopeptidasecysteine protease P32cytochrome cdensityinsightintracellular skeletonmembrane permeabilitymitochondrialmutantnecrocytosisp53 Antigenp53 Genesp53 Tumor Suppressorpathwaypolymerpolymericpro-apoptotic proteinprotein p53recruitresistantresponseskeletonssocial rolevirtual
Description preview
PROJECT SUMMARY
The actin cytoskeleton impacts virtually every function of a human cell. Sophisticated regulatory mechanisms
ensure that actin polymerizes when and where it is needed, and the assembly of actin filaments de novo is
driven by proteins called nucleation factors. While the cytoskeleton is known to provide structure and generate
forces…
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