grant
Cyst induction and growth in ADPKD
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 15 Aug 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20250-11 years oldADPKDAblationAdult Polycystic Kidney DiseaseAffectAllelesAllelic LossAllelomorphsAnimalsAutomobile DrivingAutosomal Dominant Polycystic KidneyAutosomal Dominant Polycystic Kidney DiseaseCDDPCell BodyCell DeathCell modelCellsCellular modelChildChild YouthChildren (0-21)Cis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumClonal ExpansionCollecting Kidney TubulesCysplatynaCystCystic Kidney DiseasesCystic Renal DiseasesCystic kidneyDNA RecombinationDNA mutationDataData ReportingDevelopmentDichlorodiammineplatinumDiseaseDisorderDistalDominant Polycystic Kidney DiseaseDrugsDuctDuct (organ) structureEarly treatmentEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEnvironmentEpidermal CystEpidermal Inclusion CystEpidermoid CystEpithelial CellsEpithelial cystEquilibriumEventExposure toGeneralized GrowthGenerationsGeneticGenetic ChangeGenetic DiseasesGenetic HeterogeneityGenetic RecombinationGenetic defectGenetic mutationGrowthHereditaryHeterozygoteHorn CystHybridsHypertensionIncidenceInclusion CystIndividualInheritedInjury to KidneyKeratin CystKeratinizing CystKeratinous CystKidneyKidney Collecting DuctsKidney CystKidney FailureKidney InsufficiencyKidney Urinary SystemLabelLeadLifeLithium ChlorideLive BirthLoss of HeterozygosityMediatingMediatorMedicationMiceMice MammalsModelingMolecularMurineMusMutateMutationNatureNephronsOrganoidsPKD1 genePainPainfulPatientsPb elementPeyrone's ChloridePeyrone's SaltPharmaceutical PreparationsPhenotypePilar CystPlatinum DiamminodichloridePredispositionProcessProliferatingRecombinationRenal CellRenal CystRenal FailureRenal InsufficiencyRenal functionRoleSebaceous CystSeriesSourceSusceptibilityTamoxifenTestingTissue GrowthTubularTubular formationUriniferous TubeVascular Hypertensive DiseaseVascular Hypertensive DisorderVisualizationbalancebalance functioncell behaviorcellular behaviorcis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumcollecting tubule structuredata representationdata representationsdaughter celldevelopmentaldrivingdrug/agentearly therapygenetic conditiongenetic disordergenome mutationgenome sequencingheavy metal Pbheavy metal leadheterozygosityhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderiPSiPSCiPSCsin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellkidney cellkidney functionkidney injurykidsmouse geneticsmouse modelmurine modelmutantnecrocytosisontogenypolycystic kidney disease 1 (autosomal dominant)postnatalpreventpreventingrenalrenal injurysocial roleyoungster
Description preview
Abstract:
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the world’s most common life-threatening
genetic diseases. Mutations in the genes PKD1 and PKD2 account for 85% and 15% of all ADPKD cases,
respectively. ADPKD patients are heterozygous for either PKD1 or PKD2 deleterious mutations; homozygous
mutations are considered…
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