grant
CYP4F Enzymes Regulate N-Acyl Amino Acid Signaling in Humans
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase5'-AMP-activated protein kinaseAMP-activated kinaseAMP-activated protein kinaseAMPK enzymeAcidsAddressAdult-Onset Diabetes MellitusAmino AcidsAnimal ModelAnimal Models and Related StudiesAnti-diabetic AgentsAnti-diabetic DrugsArachidonic AcidsAutoregulationBiochemicalBiologic ModelsBiologicalBiological MarkersBiological ModelsBloodBlood PlasmaBlood Reticuloendothelial SystemBody TissuesBody WeightCYP4F11CYP4F11 geneCardiometabolic DiseaseCardiometabolic DisorderCatabolismCell BodyCell Communication and SignalingCell SignalingCell modelCellsCellular modelCoronary DiseaseCoronary heart diseaseCytochrome P-450Cytochrome P-450 Enzyme SystemCytochrome P450Cytochrome P450 Family GeneCytochrome P450, Family 4, Subfamily F, Polypeptide 11Cytochrome P450, Subfamily IVF, Polypeptide 11D-GlucoseDataDextroseDiabetes MellitusDiseaseDisorderDysfunctionEicosanoidsEnergy ExpenditureEnergy MetabolismEnzyme GeneEnzymesFamilyFamily memberFatty Acid Metabolism PathwayFatty AcidsFunctional disorderFutureGWA studyGWASGenetic DeterminismGenomicsGlucoseGoalsHMG CoA reductase (NADPH) kinaseHMG CoA reductase kinaseHMG coenzyme A reductase (NADPH) kinaseHealthHeart failureHepatic CellsHepatic Parenchymal CellHepatocyteHomeostasisHumanHuman BiologyHydroxylasesHydroxylationIn VitroIndividualInsulin homeostasisIntermediary MetabolismIntracellular Communication and SignalingInvestigationIsotope LabelingJackson Heart StudyKetosis-Resistant Diabetes MellitusLaboratoriesLeucineLipidsLiver CellsMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMaturity-Onset Diabetes MellitusMeasuresMendelian randomizationMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMethodsMiceMice MammalsMitochondriaMixed Function OxidasesMixed Function OxygenasesModel SystemModelingModern ManMonooxygenasesMulti-Ethnic Study of AtherosclerosisMurineMusN hydroxylationNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityP450ParticipantPathway interactionsPhenotypePhenylalaninePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlasmaPlasma SerumPlayPreventionPropertyProteinsReactionRecombinantsRespirationReticuloendothelial System, Serum, PlasmaRiskRodentRodentiaRodents MammalsRoleSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSlow-Onset Diabetes MellitusStable Diabetes MellitusSystemT2 DMT2DT2DMTestingTherapeuticThesaurismosisTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesadiposityadult onset diabetesaminoacidanti-diabeticarachidonic metabolismbio-markersbiologicbiologic markerbiological signal transductionbiomarkerblood glucose regulationcardiac failurecardiometaboliccardiometabolismcell typecoronary disordercorpulencediabetesdisease modeldisorder modeleicosanoid metabolismendocrine factorfatty acid metabolismgene locusgenetic determinantgenetic locusgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic locationgenomic locusglucose controlglucose homeostasisglucose regulationglucose tolerancehuman population studyhydroxy fatty acidhydroxymethylglutaryl-CoA-reductase kinaseimprovedinhibitorinsightinsulin balanceinsulin controlketosis resistant diabeteslipokineslipophilicitymaturity onset diabetesmetabolism disordermetabolism measurementmetabolomicsmetabonomicsmitochondrialmodel of animalmouse modelmurine modelnovelobesity interventionobesity preventionobesity therapyobesity treatmentoxidationpathophysiologypathwayperoxisomepharmacologicprevent obesityrespiratory mechanismsocial roletherapeutic targettreatment strategytype 2 DMtype II DMtype two diabeteswhole genome association analysiswhole genome association study
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PROJECT SUMMARY
Obesity and obesity-related type 2 diabetes (T2D) pose major health threats in the US, however the early
pathophysiology of these diseases remain incompletely defined. Blood-borne lipid signaling molecules called
lipokines are an emerging class of endocrine factors that control systemic energy and glucose homeostasis
and offer…
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