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CTBI: Traumatic brain injury-induced inflammation effects on cognitive evaluations and response inhibition: Mechanisms of increased risk for suicidality

Organization VA NEW JERSEY HEALTH CARE SYSTEMLocation EAST ORANGE, UNITED STATESPosted 1 Oct 2019Deadline 30 Sept 2025 ⚠️
VANIHUS FederalResearch GrantFY20255-HT5-HT pathway5-HT system5-Hydroxytryptamine5HTAcousticsAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnimalsAntiinflammatory EffectAreaArmed Forces PersonnelAttenuatedAwardBehavioralBiological MarkersBloodBlood Reticuloendothelial SystemBrainBrain ConcussionBrain Nervous SystemBrain StemBrain TraumaBrain regionBrainstemCell NucleusCerebral ConcussionChronicCognitiveCommon Rat StrainsCommotio CerebriDataDecision MakingDifferences between sexesDiffers between sexesDrug abuseDysfunctionEncephalonEnteramineEvaluationFemaleFluoxetinFluoxetineFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingHippophaineHistoryHumanImageImpulsive BehaviorImpulsivityIndividualInflammationInflammatoryInflammatory ResponseInjuryLateralLeadLinkLiquid substanceMTBIMeasuresMental DepressionMilitaryMilitary PersonnelModelingModern ManMotorNerve CellsNerve DegenerationNerve UnitNeural CellNeurobiologyNeurocyteNeuron DegenerationNeuronsNucleusPathologicPb elementPercussionPhysiopathologyPonsPons CerebelliPons VaroliiPontinePontine structureProceduresProcessProzacQOLQuality of lifeRatRats MammalsRattusRecording of previous eventsResearchRewardsRisk FactorsSSRISSRIsSelective Serotonin Reuptake InhibitorSelective serotonin re-uptake inhibitorSerotonergic SystemSerotoninSex DifferencesSexual differencesSiteSocial isolationStartle ReactionStressSuicideSymptomsSynapsesSynapticTestingTimeTranscript Expression AnalysesTranscript Expression AnalysisTraumatic Brain InjuryVeteransWorkabuse of drugsabuses drugsanalyze gene expressionanti-inflammatory effectattenuateattenuatesbehavior testbehavioral testbio-markersbiologic markerbiomarkerbrain tissueconcussionconcussivedepressiondiscountingfMRIfatal attemptfatal suicidefluidfluid percussion injuryfrontal cortexfrontal lobegene expression analysisgene expression assayheavy metal Pbheavy metal leadhistorieshuman imagingimagingimmunoreactivityinhibitorinjuriesintent to dieliquidmalemild TBImild brain traumamild traumatic brain injurymilitary populationmodel of animalneural circuitneural circuitryneural degenerationneural inflammationneurobiologicalneurocircuitryneurodegenerationneurodegenerativeneuroinflammationneuroinflammatoryneurological degenerationneuronalneuronal degenerationnovelnucleus reticularispathophysiologypreferencepreventpreventingraphe nucleiresponseserotonergic pathwayserotonin pathwayserotonin reuptake inhibitorserotonin systemsex based differencessex-dependent differencessex-related differencessex-specific differencesstartle responsesuicidalsuicidal behaviorsuicidal risksuicidalitysuicide behaviorsuicide risksuicidessynapsesynaptic circuitsynaptic circuitrytherapeutic targettraittranscriptional profilingtraumatic brain damage♀♂

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Description preview

This Merit proposal is part of a BLR&D Collaborative Merit Award for TBI (CTBI) proposal (RFP #BX-19-006)
involving three separate but integrated proposals that together investigate the mechanisms by which TBI
enhances impulsivity and suicidal behavior in Veterans. The rationale for the collaborative project is to combine
neurobiological…

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