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Cryptic bacterial carrier proteins bridging fatty acid synthase

Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Mar 2024Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY20251,2-Dithiolane-3-pentanoic acidAcyl Carrier ProteinAcylationAddressAnabolismAntibiotic AgentsAntibiotic DrugsAntibioticsBacteriaBindingBiotinCarrier ProteinsCell divisionChargeChemicalsComplexCrosslinkerDataDrug TargetingE coliE. coliEC 2.3.1.85EnvironmentEnzyme GeneEnzyme KineticsEnzymesEquilibriumEscherichia coliFatty Acid Synthetase ComplexFatty AcidsFatty-acid synthaseFutureGeneralized GrowthGenetics-MutagenesisGoalsGonococcusGrowthHumanHuman MicrobiomeIntermediary MetabolismKineticsL monocytogenesL. monocytogenesLaboratoriesLinkLipidsLipoic AcidLipopolysaccharidesListeria monocytogenesMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMethodsMiscellaneous AntibioticModern ManMolecular InteractionMutagenesisMutagenesis Molecular BiologyN gonorrheaN. gonorrheaNeisseria gonorrhoeaeOperonP aeruginosaP. aeruginosaPathogenesisPathogenicityPathway interactionsPlayProteinsPseudomonas aeruginosaPseudomonas pyocyaneaRegulationRoleS aureusS enterica serovar TyphimuriumS typhimuriumS. aureusS. enterica TyphimuriumS. enterica serovar TyphimuriumS. typhimuriumSalmonella enterica TyphimuriumSalmonella enterica serovar TyphimuriumSalmonella typhimuriumSingle Crystal DiffractionSiteSphingolipidsStaph aureusStaphylococcus aureusStructureSystemThioctic AcidTimeTissue GrowthTitrationsTransport Protein GeneTransport ProteinsTransporter ProteinVirusVitamin HX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyalpha-Lipoic Acidbacteria pathogenbacterial pathogenbalancebalance functionbiosynthesiscoenzyme Rcomparativeconferenceconventioncrosslinkdrug discoveryenzyme activityfat metabolismfatty acid biosynthesishuman-associated microbiomeinsightlipid metabolismmembermicrobialontogenypathogenpathogenic E colipathogenic E. colipathogenic Escherichia colipathogenic bacteriapathwayprogenitorprogramsprotein crosslinkprotein protein interactionserine C-palmitoyltransferaseserine palmitoyltransferasesocial rolestructural biologysummitsymposiasymposiumtherapeutic targettool

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Project Summary. Until recently, sphingolipids within the microbial environment have been attributed to host
association, as the conventional wisdom was that bacteria did not contain their own biosynthetic pathways to
produce them. Recently, members of our team uncovered a new bacterial sphingolipid pathway involving an acyl
carrier protein…

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